Odontogenic Cysts and Tumors.

Tumours of the head and neck

Chemoprevention of oral carcinogenesis

The expression of all four ErbB receptors was compared by immunohistochemistry, using receptor-specific polyclonal antisera, in 32 invasive, 11 in situ carcinomas, six benign lesions, and 22 samples of histologically normal mucosa adjacent to specimens of carcinoma originating from oral cavity epithelium. Among invasive and in situ carcinoma, EGFR expression was the most prevalent (in 29/32 and 8/11 cases, respectively) followed by ErbB2 (17/32 and 2/11) and ErbB4 (9/32 and 1/10), while ErbB3 was only detected in invasive tumours (12/32). Specific patterns included invasive tumours with expression of EGFR (8/32) or ErbB4 (1/32) alone, as well as different receptor combinations (EGFR+ErbB2, EGFR+ErbB4, EGFR+ErbB2+ErbB3, EGFR+ErbB2+ErbB4, and all four receptors). Simultaneous expression of three or four ErbB receptors correlated with tumour invasion (p=2.2×10−4) and localized in the intermediate epithelial cell layer of well and moderately differentiated tumours. No other significant correlation with clinico-pathological features was noticed. Some benign lesions and histologically normal mucosa adjacent to carcinomas showed weak immunostaining of EGFR (10/28), ErbB2 (4/28) or ErbB4 (3/28). By comparison, overexpression, as indicated by increased staining intensity, was observed in invasive tumours for EGFR (18/32), ErbB2 (8/32), ErbB4 (3/32), and ErbB3 (3/32). Statistical evaluation demonstrated a significant association of EGFR or ErbB2 overexpression with invasive carcinoma when compared with benign lesions and apparently normal epithelium (p=5.2×10−7 and p=5×10−3, respectively). Tumour-specific overexpression of ErbB receptors and their co-expression, most frequently involving EGFR and ErbB2, in the same cell layer of neoplastic epithelium, implicate receptor heterodimers in the pathogenesis of oral squamous carcinoma. Copyright © 2001 John Wiley & Sons, Ltd.

Co-localization of multiple ErbB receptors in stratified epithelium of oral squamous cell carcinoma

The pathogenesis of oral squamous cell carcinoma involves recognised carcinogens in tobacco and/or alcohol but other factors, including viruses, may also have a role. This paper reviews the gene changes revealed in oral carcinoma, the evidence implicating viruses, and mechanisms whereby viruses may affect gene function.

Oncogenes, tumour suppressors and viruses in oral squamous carcinoma

Evaluation of epidermal growth factor receptor in squamous cell carcinoma of the oral cavity.

Carcinoma after enucleation of a calcifying odontogenic cyst: a case report.

A 1-year-old boy with an ameloblastic fibro-odontoma in the anterior mandible is presented.Ameloblastic fibro-odontoma is a rare odontogenic tumor composed of epithelial cells and mesenchymal stroma derived from tooth germ cells.The patient visited our clinic for swelling on the right incisal region of the mandible. Hard swelling of the alveolar bone was found. Radiographic examination demonstrated a cystic radiolucent area with radiopaque mass-like teeth. On December 12, 1991, the mandibular tumor was extirpated under general anesthesia. Microscopically, the tumor was composed of primitive connective tissue resembling dental pulp and odontogenic epithelium as well as enamel, dentin, and tooth germ. This lesion was histologically diagnosed as ameloblastic fibro-odontoma. This case has been followed-up for 2 years 6 months and there has been no evidence of reccurence.

A case of an ameloblastic fibro-odontoma in the mandibular incisal region of a one-year-old boy

東京医科歯科大学歯学部附属病院第一口腔外科を受診した1980年から1994年までの上顎歯肉・硬口蓋原発扁平上皮癌45例について臨床病理学的に検討を加えた。T分類ではT1: 7例 (15.6%) , T2: 15例 (33.3%) , T: 9例 (20.0%) , T4: 14例 (31.1%) であった。このうち24例 (53.2%) で三者併用療法が施行された。上顎歯肉・硬口蓋扁平上皮癌の5年累積生存率は58.9% (T1: 80.0%, T2: 83.6%, T3: 40.0%, T4: 42.8%) で, 三者併用療法では60.7%であった。腫瘍の発育との検討では, 内向性発育を示す腫瘍が, 外向性発育を示すものに比べて治療成績が悪く, 病理組織学的に, 生検時のY-K分類では, 浸潤傾向の少ない3型以下の66.6%に比べて, より浸潤傾向の強い4C, 4D型では33.3%と, 明らかに浸潤傾向が強いほど治療成績が悪かった。骨吸収のない症例では全例が生存し, 歯槽骨に骨吸収を示す症例では57.1% (P<0.05) , 骨吸収が上顎洞に達する症例では44.4% (<0.01) と, 腫瘍が上方へ発育するにつれて治療成績は悪化した。以上の結果から, 腫瘍の浸潤様式と骨吸収の程度が, 上顎歯肉・硬口蓋扁平上皮癌の予後を左右する大きな因子である可能性が示唆された。

https://www.jstage.jst.go.jp/article/jsot1989/9/4/9_4_314/_pdf

Clinicopathological study on squamous cell carcinoma of the upper alveolus and gingiva and hard palate.

1978年より1988年までの11年間に東京医科歯科大学歯学部第一口腔外科を受診した舌扁平上皮癌1次症例 (177例) のうち, T1 (56例), T2 (80例) 症例の生検標本を病理組織学的 (WHO分類, Y-K分類) に2検索し, 後発頸部リンパ節転移 (以後, 後発頸転移と略) との関係を検討した。後発頸転移は, WHO分類, Y-K分類とも Grade が進むにつれ増加していた。治療法別にみると, 後発頸転移は, 外科療法群に比べ放射線療法群に多かった。放射線療法群では, WHO分類 Grade IIIならびにY-K分類 Grade 4C, 4Dに後発頸転移例が多い傾向であったが, 外科療法群では, 一定の傾向はみられなかった。

Takafumi Yamada

Papers

Evaluation of epidermal growth factor receptor in squamous cell carcinoma of the oral cavity.

Carcinoma after enucleation of a calcifying odontogenic cyst: a case report.

A case of an ameloblastic fibro-odontoma in the mandibular incisal region of a one-year-old boy

Clinicopathological study on squamous cell carcinoma of the upper alveolus and gingiva and hard palate.

A clinicopathological study of the cervical lymphonde metastasis for the T1, T2 cases of the squamous cell carcinoma of the tongue