Yi-Lin Chan

TL;DR: The secretion profiles of pro-inflammatory cytokines were found significantly to be reduced in 1-5 mg/mL dose ranges of SHSP treatments, and RT-PCR analysis suggested SHSP inhibits the LPS-induced mRNA expressions of IL-β, iNOS, and COX-2 in a dose-dependent manner.

TL;DR: It is demonstrated that siRNAs directed against Spike sequences and the 3′-UTR can inhibit the replication of SARS-CoV in Vero-E6 cells, and holds out promise for the development of an effective antiviral agent against SARS -CoV.

TL;DR: Viperin gene expression is highly induced at the RNA level by Japanese encephalitis virus and Sindbis virus and that viperin protein is degraded in JEV-infected cells through a proteasome-dependent mechanism, suggesting it is negatively regulated at the protein level to counteract its antiviral effect.

TL;DR: TAL6 appears to be involved in cancer invasion and metastasis, and real-time reverse transcription-PCR of lung cancer specimens showed that increased expression of TAL6 was significantly associated with early postoperative relapse and shorter survival in squamous cell lung cancer patients.

TL;DR: It is discovered that administration of fucoidan has prophylactic effects on mitigation of cachectic body weight loss and improvement of lung masses in tumor-inoculated mice, and is suitable to act as a chemo-preventative agent for minimizing cachectic symptoms and inhibiting lung carcinoma metastasis through down-regulating metastatic factors VEGF and MMPs.