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Yi-Lin Chan
Researcher at Chinese Culture University
Publications - 43
Citations - 1657
Yi-Lin Chan is an academic researcher from Chinese Culture University. The author has contributed to research in topics: Cancer & Lung cancer. The author has an hindex of 23, co-authored 42 publications receiving 1359 citations. Previous affiliations of Yi-Lin Chan include National Defense Medical Center & Academia Sinica.
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Journal ArticleDOI
Inhibition of Lipopolysaccharide (LPS)-Induced Inflammatory Responses by Sargassum hemiphyllum Sulfated Polysaccharide Extract in RAW 264.7 Macrophage Cells
Pai-An Hwang,Shih-Yung Chien,Yi-Lin Chan,Mei-Kuang Lu,Chwen-Herng Wu,Zwe-Ling Kong,Chang-Jer Wu +6 more
TL;DR: The secretion profiles of pro-inflammatory cytokines were found significantly to be reduced in 1-5 mg/mL dose ranges of SHSP treatments, and RT-PCR analysis suggested SHSP inhibits the LPS-induced mRNA expressions of IL-β, iNOS, and COX-2 in a dose-dependent manner.
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Inhibition of SARS-CoV replication by siRNA.
TL;DR: It is demonstrated that siRNAs directed against Spike sequences and the 3′-UTR can inhibit the replication of SARS-CoV in Vero-E6 cells, and holds out promise for the development of an effective antiviral agent against SARS -CoV.
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The Cellular Antiviral Protein Viperin Is Attenuated by Proteasome-Mediated Protein Degradation in Japanese Encephalitis Virus-Infected Cells
TL;DR: Viperin gene expression is highly induced at the RNA level by Japanese encephalitis virus and Sindbis virus and that viperin protein is degraded in JEV-infected cells through a proteasome-dependent mechanism, suggesting it is negatively regulated at the protein level to counteract its antiviral effect.
Journal Article
Tumor-associated antigen L6 and the invasion of human lung cancer cells
Yu-Rong Kao,Jin-Yuan Shih,Wei-Chun Wen,Ya-Ping Ko,Bing-Mae Chen,Yi-Lin Chan,Yi-Wen Chu,Pan-Chyr Yang,Pan-Chyr Yang,Pan-Chyr Yang,Cheng-Wen Wu,Steve R. Roffler +11 more
TL;DR: TAL6 appears to be involved in cancer invasion and metastasis, and real-time reverse transcription-PCR of lung cancer specimens showed that increased expression of TAL6 was significantly associated with early postoperative relapse and shorter survival in squamous cell lung cancer patients.
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Prophylactic Administration of Fucoidan Represses Cancer Metastasis by Inhibiting Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinases (MMPs) in Lewis Tumor-Bearing Mice
Tse-Hung Huang,Tse-Hung Huang,Yi-Han Chiu,Yi-Lin Chan,Ya-Huang Chiu,Hang Wang,Kuo-Chin Huang,Tsung-Lin Li,Kuang-Hung Hsu,Chang-Jer Wu +9 more
TL;DR: It is discovered that administration of fucoidan has prophylactic effects on mitigation of cachectic body weight loss and improvement of lung masses in tumor-inoculated mice, and is suitable to act as a chemo-preventative agent for minimizing cachectic symptoms and inhibiting lung carcinoma metastasis through down-regulating metastatic factors VEGF and MMPs.