A
A. Barathi
Researcher at National University of Singapore
Publications - 13
Citations - 392
A. Barathi is an academic researcher from National University of Singapore. The author has contributed to research in topics: Gene & Sclera. The author has an hindex of 8, co-authored 11 publications receiving 339 citations. Previous affiliations of A. Barathi include Singapore National Eye Center.
Papers
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Journal ArticleDOI
Long-term evaluation of AAV-mediated sFlt-1 gene therapy for ocular neovascularization in mice and monkeys
Chooi May Lai,Weiyong Shen,Weiyong Shen,M. Brankov,M. Brankov,Yvonne K. Y. Lai,Yvonne K. Y. Lai,Nigel L. Barnett,Shu Yen Lee,Ian Yeo,Ranjana Mathur,Joseph E.S. Ho,Paul Pineda,A. Barathi,Chong Lye Ang,Ian J. Constable,Elizabeth Rakoczy +16 more
TL;DR: It is shown that adeno-associated virus-mediated expression of sFlt-1, a soluble form of the Flt-1 VEGF receptor, was maintained for up to 8 and 17 months postinjection in mice and in monkeys, respectively, suggesting that AAV-mediated secretion gene therapy could be considered for treatment of retinal and choroidal neovascularizations.
Journal ArticleDOI
Preclinical safety evaluation of subretinal AAV2.sFlt-1 in non-human primates
Chooi-May Lai,Marie J Estcourt,Robyn Himbeck,Sy Lee,I Yew-An Yeo,Chi D Luu,BK Loh,MW Lee,A. Barathi,J Villano,Chong Lye Ang,R G van der Most,Ian J. Constable,D Dismuke,Richard Jude Samulski,Mariapia A. Degli-Esposti,Elizabeth Rakoczy +16 more
TL;DR: The data indicate that gene therapy with subretinal AAV2.sFlt-1 is safe and well tolerated, and therefore promising for the long-term treatment of neovascular diseases of the eye.
Journal ArticleDOI
Proteomic analysis of rabbit tear fluid: Defensin levels after an experimental corneal wound are correlated to wound closure.
Lei Zhou,Roger W. Beuerman,Liqun Huang,A. Barathi,Yong Hwee Foo,Sam Fong Yau Li,Fook Tim Chew,Donald T.H. Tan +7 more
TL;DR: The increased availability of defensins in the tears during healing suggests that these peptides could protect the cornea from microbial attack during a period of increased vulnerability.
Journal ArticleDOI
Analysis of rabbit tear proteins by high-pressure liquid chromatography/electrospray ionization mass spectrometry
TL;DR: LC/ESI-MS was developed as a fast, reproducible and simple method for the identification and analysis of many of the protein components of the tears and allows quantification of each component resolved in the chromatogram.
Journal ArticleDOI
Surgical Removal of Internal Limiting Membrane and Layering of AAV Vector on the Retina Under Air Enhances Gene Transfection in a Nonhuman Primate.
Kelvin Yi Chong Teo,Shu Yen Lee,A. Barathi,Sai Bo Bo Tun,Licia Tan,Ian J. Constable,Ian J. Constable +6 more
TL;DR: An efficacious and safe method of AAV2 gene delivery, taking into account the potential need for repeat treatments, appears to be the surgical removal of ILM and layering of A AV under air.