A. Benakis

TL;DR: Treatment of p53 wild-type TK6 and p53 mutated WTK1 lymphoblastic cells showed that mutational status of the tumor suppressor p53 did not influence sensitivity to artesunate, indicating that artemisinins plus ferrous iron may affect tumor cells more than normal cells.

TL;DR: Whole-body autoradiography and quantification in organs and tissues as a function of time showed that the distribution of radioactivity throughout the body is general with the highest level in the kidineys, pelvis, liver and hypophysis 1 hour after administration.

TL;DR: None of the metabolites found in the urine and plasma of rats, dogs and humans was found in human urine; the pharmacological properties of sulpiride could therefore be attributed to the unchanged product.

TL;DR: To quantify the changes in plasma concentrations of atracurium and laudanosine induced by the lack of hepatic function and circulation, the authors studied nine domestic pigs undergoing an orthotopic liver transplantation, and three control animals without surgery, using atracuium as the muscle relaxant.

TL;DR: There is a similar decrease in the recovery rate of vecuronium-induced neuromuscular blockade and in the metabolic rate of 14C-labeled aminopyrine during the progressive recovery of hepatic function Immediately after un-clamping of the liver vessels.