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A. Brian Jones
Researcher at Imperial College London
Publications - 3
Citations - 106
A. Brian Jones is an academic researcher from Imperial College London. The author has contributed to research in topics: Pyran & Derivative (chemistry). The author has an hindex of 3, co-authored 3 publications receiving 104 citations.
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Journal ArticleDOI
A highly convergent total synthesis of the spiroacetal macrolide (+)-milbemycinβ1
Steven V. Ley,Neville J. Anthony,Alan Armstrong,M.Gabriella Brasca,Trafford Clarke,David Culshaw,Christine Greck,Peter Grice,A. Brian Jones,Barry Lygo,Andrew Madin,Richard N. Sheppard,Alexandra M. Z. Slawin,David J. Williams +13 more
TL;DR: In this article, a highly convergent synthesis of the macrolide natural product milbemycin β1 is reported, which includes the introduction of the C11-C15 side chain by selective ring opening of a symmetrical 1,4-pentane bis-epoxide, followed by reaction with the anion derived from the 2,3-trans-dimethyl-6-phenylsulphonyl pyran.
Journal ArticleDOI
Synthesis of the monocyclic nonaromatic C-1 to C-10 fragments of the milbemycins and avermectins.
TL;DR: In this article, the C-1 to C-10 monocyclic nonaromatic fragments of the milbemycins and avermectins have been synthesized by adding 2-lithio-4-phenylthiobut-1-ene to a 3-hydroxycyclohexanone derivative.
Journal ArticleDOI
Synthesis of a novel 3, 4-dihydromilbemycin analogue.
TL;DR: The synthesis of a 3, 4-dihydromilbemycin derivative has been achieved by Julia coupling of the trianion of a C-1 to C-10 "southern" fragment with a C -11 to C -25 "northern" unit.