A
A D Steinberg
Researcher at National Institutes of Health
Publications - 95
Citations - 6151
A D Steinberg is an academic researcher from National Institutes of Health. The author has contributed to research in topics: T cell & B cell. The author has an hindex of 37, co-authored 95 publications receiving 6051 citations.
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Journal ArticleDOI
Therapy of lupus nephritis. Controlled trial of prednisone and cytotoxic drugs.
Howard A. Austin,John H. Klippel,James E. Balow,N. G.H. Le Riche,A D Steinberg,Paul H. Plotz,John L. Decker +6 more
TL;DR: It is concluded that, as compared with high-dose oral prednisone alone, treatment of lupus glomerulonephritis with intravenous cyclophosphamide reduces the risk of end-stage renal failure with few serious complications.
Journal ArticleDOI
Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis
Dimitrios T. Boumpas,Howard A. Austin,James E. Balow,Ellen M. Vaughan,Cheryl Yarboro,John H. Klippel,A D Steinberg +6 more
TL;DR: An extended course of pulse cyclophosphamide is more effective than 6 months of pulse methylprednisolone in preserving renal function in patients with severe lupus nephritis, and addition of a quarterly maintenance regimen to monthly pulse cyclophileosphamide reduces the rate of exacerbations.
Journal Article
Effects of thymectomy or androgen administration upon the autoimmune disease of MRL/Mp-lpr/lpr mice.
TL;DR: It is suggested that different T cell abnormalities may underlie the development of autoimmunity in MRL/lpr and NZB X NZW F1 mice, but that disease may be expressed through a common androgen-sensitive pathway.
Journal ArticleDOI
Renal flares are common in patients with severe proliferative lupus nephritis treated with pulse immunosuppressive therapy: long-term followup of a cohort of 145 patients participating in randomized controlled studies.
Gabor G. Illei,Kazuki Takada,D. Parkin,Howard A. Austin,Marianna Crane,Cheryl Yarboro,Ellen M. Vaughan,Takashi Kuroiwa,C. L. Danning,J. Pando,A D Steinberg,M. F. Gourley,John H. Klippel,James E. Balow,Dimitrios T. Boumpas +14 more
TL;DR: Renal flares are an important feature of the natural history of lupus nephritis and provide an opportunity for additional preventive strategies, as well as measures of efficacy in future therapeutic trials.
Journal Article
Cytokine gene expression after in vivo primary immunization with goat antibody to mouse IgD antibody.
A. Svetic,Fred D. Finkelman,Y C Jian,C W Dieffenbach,D E Scott,K F McCarthy,A D Steinberg,William C. Gause +7 more
TL;DR: The results demonstrate a specific and highly reproducible cytokine gene expression pattern during the course of a primary in vivo immune response that is marked by an absence of a clear-cut Th1/Th2 dichotomy.