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A E Holley
Researcher at Medical Research Council
Publications - 1
Citations - 21
A E Holley is an academic researcher from Medical Research Council. The author has contributed to research in topics: Protoporphyrin & Methyl group. The author has an hindex of 1, co-authored 1 publications receiving 19 citations.
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Isolation of two N-monosubstituted protoporphyrins, bearing either the whole drug or a methyl group on the pyrrole nitrogen atom, from liver of mice given griseofulvin.
TL;DR: A hepatic green pigment with inhibitory properties towards the enzyme ferrochelatase has been isolated from the liver of mice treated with griseofulvin and identified as N-methylprotoporphyrin, and the fragmentation of this adduct in tandem m.s.s suggests that griseefulvin is bound to the pyrrole nitrogen through one of its carbon atoms.