There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality.

Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

I and i

抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

SciPy is an open source scientific computing library for the Python programming language. SciPy 1.0 was released in late 2017, about 16 years after the original version 0.1 release. SciPy has become a de facto standard for leveraging scientific algorithms in the Python programming language, with more than 600 unique code contributors, thousands of dependent packages, over 100,000 dependent repositories, and millions of downloads per year. This includes usage of SciPy in almost half of all machine learning projects on GitHub, and usage by high profile projects including LIGO gravitational wave analysis and creation of the first-ever image of a black hole (M87). The library includes functionality spanning clustering, Fourier transforms, integration, interpolation, file I/O, linear algebra, image processing, orthogonal distance regression, minimization algorithms, signal processing, sparse matrix handling, computational geometry, and statistics. In this work, we provide an overview of the capabilities and development practices of the SciPy library and highlight some recent technical developments.

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SciPy 1.0--Fundamental Algorithms for Scientific Computing in Python

The combination of seven-year data from WMAP and improved astrophysical data rigorously tests the standard cosmological model and places new constraints on its basic parameters and extensions. By combining the WMAP data with the latest distance measurements from the baryon acoustic oscillations (BAO) in the distribution of galaxies and the Hubble constant (H0) measurement, we determine the parameters of the simplest six-parameter ΛCDM model. The power-law index of the primordial power spectrum is ns = 0.968 ± 0.012 (68% CL) for this data combination, a measurement that excludes the Harrison–Zel’dovich–Peebles spectrum by 99.5% CL. The other parameters, including those beyond the minimal set, are also consistent with, and improved from, the five-year results. We find no convincing deviations from the minimal model. The seven-year temperature power spectrum gives a better determination of the third acoustic peak, which results in a better determination of the redshift of the matter-radiation equality epoch. Notable examples of improved parameters are the total mass of neutrinos, � mν < 0.58 eV (95% CL), and the effective number of neutrino species, Neff = 4.34 +0.86 −0.88 (68% CL), which benefit from better determinations of the third peak and H0. The limit on a constant dark energy equation of state parameter from WMAP+BAO+H0, without high-redshift Type Ia supernovae, is w =− 1.10 ± 0.14 (68% CL). We detect the effect of primordial helium on the temperature power spectrum and provide a new test of big bang nucleosynthesis by measuring Yp = 0.326 ± 0.075 (68% CL). We detect, and show on the map for the first time, the tangential and radial polarization patterns around hot and cold spots of temperature fluctuations, an important test of physical processes at z = 1090 and the dominance of adiabatic scalar fluctuations. The seven-year polarization data have significantly improved: we now detect the temperature–E-mode polarization cross power spectrum at 21σ , compared with 13σ from the five-year data. With the seven-year temperature–B-mode cross power spectrum, the limit on a rotation of the polarization plane due to potential parity-violating effects has improved by 38% to Δα =− 1. 1 ± 1. 4(statistical) ± 1. 5(systematic) (68% CL). We report significant detections of the Sunyaev–Zel’dovich (SZ) effect at the locations of known clusters of galaxies. The measured SZ signal agrees well with the expected signal from the X-ray data on a cluster-by-cluster basis. However, it is a factor of 0.5–0.7 times the predictions from “universal profile” of Arnaud et al., analytical models, and hydrodynamical simulations. We find, for the first time in the SZ effect, a significant difference between the cooling-flow and non-cooling-flow clusters (or relaxed and non-relaxed clusters), which can explain some of the discrepancy. This lower amplitude is consistent with the lower-than-theoretically expected SZ power spectrum recently measured by the South Pole Telescope Collaboration.

/pdf/seven-year-wilkinson-microwave-anisotropy-probe-wmap-19dgu0rhy7.pdf

Seven-year wilkinson microwave anisotropy probe (wmap *) observations: cosmological interpretation

Deposits of clastic carbonate-dominated (calciclastic) sedimentary slope systems in the rock record have been identified mostly as linearly-consistent carbonate apron deposits, even though most ancient clastic carbonate slope deposits fit the submarine fan systems better. Calciclastic submarine fans are consequently rarely described and are poorly understood. Subsequently, very little is known especially in mud-dominated calciclastic submarine fan systems. Presented in this study are a sedimentological core and petrographic characterisation of samples from eleven boreholes from the Lower Carboniferous of Bowland Basin (Northwest England) that reveals a >250 m thick calciturbidite complex deposited in a calciclastic submarine fan setting. Seven facies are recognised from core and thin section characterisation and are grouped into three carbonate turbidite sequences. They include: 1) Calciturbidites, comprising mostly of highto low-density, wavy-laminated bioclast-rich facies; 2) low-density densite mudstones which are characterised by planar laminated and unlaminated muddominated facies; and 3) Calcidebrites which are muddy or hyper-concentrated debrisflow deposits occurring as poorly-sorted, chaotic, mud-supported floatstones. These

Phd by thesis

Mode control is crucial for the high-precision interferometry such as gravitational-wave detectors. We report here the design and characterisation of a linear, high dynamic range, spherically deformable, adaptive mirror that is adhesive-free and low cost.

/pdf/adhesive-free-high-optical-quality-deformable-mirror-qzn3uz4r7i.pdf

Adhesive-free, high optical quality deformable mirror

The ratio of baryonic to dark matter in present-day galaxies constrains galaxy formation theories and can be determined empirically via the baryonic Tully-Fisher relation (BTFR), which compares a galaxy’s baryonic mass (Mbary) to its maximum rotation velocity (Vmax). The BTFR is well-determined at Mbary> 10 8 M , but poorly constrained at lower masses due to small samples and the challenges of measuring rotation velocities in this regime. For 25 galaxies with high-quality data and Mbary. 10 M , we estimate Mbary from infrared, optical, and HI observations and Vmax from the Hi gas rotation. Many of the Vmax values are lower limits because the velocities are still rising at the edge of the detected HI disks; consequently, most of our sample has lower velocities than expected from extrapolations of the BTFR at higher masses. To estimate Vmax, we map each galaxy to a dark matter halo assuming density profiles with and without cores, and find that the cored profiles match the data better. When we compare the Vmax values derived from the cored density profiles to our Mbary measurements, we find a turndown of the BTFR at low masses that is consistent with CDM predictions and implying baryon fractions of 1-10% of the cosmic value. Although we are limited by the sample size and assumptions inherent in mapping measured rotational velocities to theoretical rotation curves, our results suggest that the galaxy formation efficiency drops at masses below Mbary∼ 10 M , corresponding to M200∼ 10 M .

The turn-down of the baryonic tully-fisher relation at low galaxy masses

Testing the standard cosmological model ($\Lambda$CDM) at small scales is challenging. Galaxies that inhabit low-mass dark matter halos provide an ideal test bed for dark matter models by linking observational properties of galaxies at small scales (low mass, low velocity) to low-mass dark matter halos. However, the observed kinematics of these galaxies do not align with the kinematics of the dark matter halos predicted to host them, obscuring our understanding of the low-mass end of the galaxy-halo connection. We use deep HI observations of low-mass galaxies at high spectral resolution in combination with cosmological simulations of dwarf galaxies to better understand the connection between dwarf galaxy kinematics and low-mass halos. Specifically, we use HI line widths to directly compare to the maximum velocities in a dark matter halo, and find that each deeper measurement approaches the expected one-to-one relationship between the observed kinematics and the predicted kinematics in $\Lambda$CDM. We also measure baryonic masses and place these on the Baryonic Tully-Fisher relation (BTFR). Again, our deepest measurements approach the theoretical predictions for the low-mass end of this relation, a significant improvement on similar measurements based on line widths measured at 50\% and 20\% of the peak. Our data also hints at the rollover in the BTFR predicted by hydrodynamical simulations of $\Lambda$CDM for low-mass galaxies.

A. F. Brooks

Papers

Adhesive-free, high optical quality deformable mirror

The turn-down of the baryonic tully-fisher relation at low galaxy masses

Closing the Gap between Observed Low-Mass Galaxy HI Kinematics and CDM Predictions