There will be one written paper of three hours duration carrying 70 marks divided into two parts. Part 1 (20 marks) will consist of compulsory short answer questions on the entire syllabus. Part 2 (50 marks) will consist of three sections. Each section will have three questions. The candidates will be expected to answer five questions in all choosing at least one from each section. Project work will carry 30 marks. The project needs to be done under the supervision of the teacher. The project work will be evaluated by a Visiting Examiner (who has expertise in that specific area), appointed locally and approved by the Council.

Environmental Science (AS)

Objective: To review the evidence for “the Mellanby effect”, that is, whether the response to a given blood alcohol concentration (BAC) is more marked when BAC is rising than at the same concentration when BAC is falling.Methods: We systematically searched the databases EMBASE, Medline, and Scopus up to and including December 2016 using text words “tolerance”, “ascending”, “descending” or “Mellanby” with Medline term “exp *alcohol/” or “exp *drinking behavior/” or equivalent. Articles were identified for further examination by title or abstract; full text articles were retained for analysis if they dealt with acute (within dose) alcohol tolerance in human subjects and provided quantitative data on both the ascending and descending parts of the BAC–time curve. Reference lists of identified works were scanned for other potentially relevant material. We extracted and analyzed data on the subjective and objective assessment of alcohol effects.Results: We identified and screened 386 unique articles, of...

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A systematic review of the evidence for acute tolerance to alcohol – the “Mellanby effect”

The toxicity data of 90 nitroaromatic compounds related to their 50% lethal dose concentration for rats (LD50) were analyzed to develop quantitative structure-activity relationship (QSAR) models. Quantum-chemically calculated descriptors together with molecular descriptors generated by DRAGON, PaDEL, and HiT-QSAR software were utilized to build QSAR models. Quality and validity of the models were determined by internal and external validation techniques. The results show that the toxicity of nitroaromatic compounds depends on various factors, such as the number of nitro-groups, the topological state, and the presence of certain structural fragments. The developed models based on the largest (to date) dataset of nitroaromatics in vivo toxicity showed a good predictive ability. The results provide important input that could be applied in a preliminary assessment of nitroaromatic compounds' toxicity to mammals. Environ Toxicol Chem 2017;36:2227-2233. © 2017 SETAC.

In vivo toxicity of nitroaromatics: A comprehensive quantitative structure–activity relationship study

Electrochemical sensor-based barium zirconate on sulphur-doped graphitic carbon nitride for the simultaneous determination of nitrofurantoin (antibacterial agent) and nilutamide (anticancer drug)

Electrochemical investigations of DNA-Intercalation potency of bisnitrophenoxy compounds with different alkyl chain lengths.

Nitroaromatic compounds and the products of their degradation are toxic to bacteria, cells and animals. Various studies have been carried out to better understand the mechanism of toxicity of aromatic nitrocompounds and their relationship to humans and the environment. Recent data relate cytotoxicity of nitroaromatic compounds to their single- or two-electron enzymatic reduction. However, mechanisms of animal toxicity could be more complex. This work investigates the estimated reduction and oxidation potentials of 34 nitroaromatic compounds using quantum chemical approaches. All geometries were optimized with density functional theory (DFT) using the solvation model based on density (SMD) and polarizable continuum model (PCM) solvent model protocols. Quantitative structure–activity/property (QSAR/QSPR) models were developed using descriptors obtained from quantum chemical optimizations as well as the DRAGON software program. The QSAR/QSPR equations developed consist of two to four descriptors. Cor...

A. Gooch

Papers

A quantum chemical based toxicity study of estimated reduction potential and hydrophobicity in series of nitroaromatic compounds.