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A. Steup
Researcher at Grünenthal GmbH
Publications - 20
Citations - 1161
A. Steup is an academic researcher from Grünenthal GmbH. The author has contributed to research in topics: Tapentadol & Oxycodone. The author has an hindex of 9, co-authored 19 publications receiving 1105 citations. Previous affiliations of A. Steup include Center for Global Development.
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Journal ArticleDOI
Efficacy and safety of tapentadol extended release for the management of chronic low back pain: results of a prospective, randomized, double-blind, placebo- and active-controlled Phase III study
Robert Buynak,D.Y. Shapiro,Akiko Okamoto,Ilse Van Hove,Christine Rauschkolb,A. Steup,Bernd Lange,Claudia Lange,Mila Etropolski +8 more
TL;DR: Tapentadol ER effectively relieved moderate to severe chronic low back pain over 15 weeks and had better gastrointestinal tolerability than oxycodone HCl CR and had a lower incidence of treatment-emergent AEs than oxy codone CR.
Journal ArticleDOI
Efficacy and safety of Tapentadol extended release compared with oxycodone controlled release for the management of moderate to severe chronic pain related to osteoarthritis of the knee: a randomized, double-blind, placebo- and active-controlled phase III study.
Marc Afilalo,Mila Etropolski,Brigitte Kuperwasser,Kathy Kelly,Akiko Okamoto,Ilse Van Hove,A. Steup,Bernd Lange,Christine Rauschkolb,Juergen Haeussler +9 more
TL;DR: Treatment with tapentadol ER 100–250 mg twice daily or oxycodone HCl CR 20–50mg twice daily was effective for the management of moderate to severe chronic osteoarthritis-related knee pain, with substantially lower incidences of gastrointestinal-related TEAEs associated with treatment withTapentadl ER than with oxy codone CR.
Journal ArticleDOI
Long-term safety and tolerability of tapentadol extended release for the management of chronic low back pain or osteoarthritis pain.
James E. Wild,Stefan Grond,Brigitte Kuperwasser,Jane S. Gilbert,Bettyanne McCann,Bernd Lange,A. Steup,T. Häufel,Mila Etropolski,Christine Rauschkolb,Robert Lange +10 more
TL;DR: In this article, the authors evaluated the long-term safety and tolerability of tapentadol extended release (ER) in patients with chronic knee or hip osteoarthritis pain or low back pain.
Journal ArticleDOI
Efficacy and safety of tapentadol prolonged release for chronic osteoarthritis pain and low back pain.
Bernd Lange,Brigitte Kuperwasser,Akiko Okamoto,A. Steup,Thomas Häufel,Judy Ashworth,Mila Etropolski +6 more
TL;DR: Tapentadol PR (100-250 mg twice daily) was efficacious and provided efficacy that was similar to oxycodone HCl CR (20–50 mg once daily) for the management of chronic osteoarthritis knee and low back pain, with a superior gastrointestinal tolerability profile and fewer treatment discontinuations.
Journal ArticleDOI
Single dose analgesic efficacy of tapentadol in postsurgical dental pain: the results of a randomized, double-blind, placebo-controlled study.
TL;DR: Single oral doses of tapentadol 75 mg or higher effectively reduced moderate-to-severe postoperative dental pain in a dose-related fashion and were well-tolerated relative to morphine, suggesting that tapentdol is a highly effective, centrally acting analgesic with a favorable side effect profile and rapid onset of action.