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A. William Blackstock
Researcher at University of North Carolina at Chapel Hill
Publications - 7
Citations - 435
A. William Blackstock is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Cancer & Gemcitabine. The author has an hindex of 3, co-authored 7 publications receiving 426 citations.
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Journal ArticleDOI
Phase I Trial of Twice-Weekly Gemcitabine and Concurrent Radiation in Patients With Advanced Pancreatic Cancer
A. William Blackstock,Stephen A. Bernard,Frederick Richards,Kaye S. Eagle,L. Douglas Case,Michael E. Poole,Paul D. Savage,Joel E. Tepper +7 more
TL;DR: A dose of twice-weekly gemcitabine at a 40 mg/m(2) dose produced mild thrombocytopenia, neutropania, nausea, and vomiting when delivered with concurrent radiation to the upper abdomen in patients with advanced pancreatic cancer, suggesting this regimen is well tolerated and may possess significant activity.
Journal ArticleDOI
Randomized Phase II Trial of Induction Chemotherapy Followed by Concurrent Chemotherapy and Dose-Escalated Thoracic Conformal Radiotherapy (74 Gy) in Stage III Non–Small-Cell Lung Cancer: CALGB 30105
Mark A. Socinski,A. William Blackstock,Jeffrey A. Bogart,Xiaofei Wang,Michael T. Munley,Julian G. Rosenman,Lin Gu,Gregory A. Masters,Peter Ungaro,Arthur M. Sleeper,M. Green,Antonius A. Miller,Everett E. Vokes +12 more
TL;DR: Arm A reached the primary end point with an estimated MST longer than 18 months and will be compared with a standard dose of TRT in a planned randomized phase III trial in the United States cooperative groups.
Journal ArticleDOI
Tumor retention of 5-fluorouracil following irradiation observed using 19F nuclear magnetic resonance spectroscopy
TL;DR: Preliminary experiments suggest the enhanced cytotoxicity seen with concurrent 5FU and radiation is related to prolonged tumor retention of 5FU induced by radiation, consistent with the hypothesis that radiation is potentiating the cytotoxic effects of5FU.