A
Aaron Lefkowitz
Researcher at Harvard University
Publications - 1
Citations - 745
Aaron Lefkowitz is an academic researcher from Harvard University. The author has contributed to research in topics: Innate immune system & Antimicrobial peptides. The author has an hindex of 1, co-authored 1 publications receiving 586 citations.
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Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease
Deepak Kumar,Se Hoon Choi,Kevin J. Washicosky,William A. Eimer,Stephanie Tucker,Jessica Ghofrani,Aaron Lefkowitz,Gawain McColl,Lee E. Goldstein,Rudolph E. Tanzi,Robert D. Moir +10 more
TL;DR: In vivo data showing that Aβ expression protects against fungal and bacterial infections in mouse, nematode, and cell culture models of AD are presented, and Aβ oligomerization, a behavior traditionally viewed as intrinsically pathological, may be necessary for the antimicrobial activities of the peptide are shown.