A
Adriaan M. Louis
Publications - 4
Citations - 103
Adriaan M. Louis is an academic researcher. The author has contributed to research in topics: Steric effects & Isoquinoline. The author has an hindex of 3, co-authored 4 publications receiving 96 citations.
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Dioncophylline E from Dioncophyllum thollonii, the first 7,3'-coupled dioncophyllaceous naphthylisoquinoline alkaloid.
Gerhard Bringmann,Kim Messer,Kristina Wolf,Jörg Mühlbacher,Matthias Grüne,Reto Brun,Adriaan M. Louis +6 more
TL;DR: Dioncophylline E exhibits good antimalarial activity against both chloroquine-sensitive and -resistant strains of Plasmodium falciparum while its antitrypanosomal activity against Trypanosoma cruzi is weak and that against T. brucei rhodesiense is moderate.
Journal ArticleDOI
Cis- and trans-isoshinanolone from Dioncophyllum thollonii : absolute configuration of two 'known', wide-spread natural products
Gerhard Bringmann,Miriam Münchbach,Kim Messer,D. Koppler,Manuela Michel,O. Schupp,Matthias Wenzel,Adriaan M. Louis +7 more
TL;DR: A new ruthenium-catalyzed oxidative degradation procedure, related to the well-established stereoanalysis of 1,3-dimethyltetrahydroisoquinolines, was elaborated, which allows to unambiguously attribute the absolute configuration of these natural products.
Journal ArticleDOI
Acetogenic isoquinoline alkaloids: CXXI. Use of on-line high-performance liquid chromatography–nuclear magnetic resonance spectrometry coupling in phytochemical screening studies: rapid identification of metabolites in Dioncophyllum thollonii
TL;DR: In this article, a strategy for the rapid identification of secondary metabolites in plant extracts is presented, based upon on-line coupling of high-performance liquid chromatography with nuclear magnetic resonance detection.