A
Adrian L. Watson
Researcher at University of Cambridge
Publications - 20
Citations - 2772
Adrian L. Watson is an academic researcher from University of Cambridge. The author has contributed to research in topics: Placenta & Syncytiotrophoblast. The author has an hindex of 14, co-authored 19 publications receiving 2548 citations. Previous affiliations of Adrian L. Watson include University College London.
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Journal ArticleDOI
Onset of Maternal Arterial Blood Flow and Placental Oxidative Stress: A Possible Factor in Human Early Pregnancy Failure
Eric Jauniaux,Adrian L. Watson,Joanne Hempstock,Yi-Ping Bao,Jeremy N. Skepper,Graham J. Burton +5 more
TL;DR: In this article, the authors measured changes in the oxygen tension within the human placenta associated with onset of the maternal arterial circulation at the end of the first trimester of pregnancy, and the impact on placental tissues.
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Uterine Glands Provide Histiotrophic Nutrition for the Human Fetus during the First Trimester of Pregnancy
TL;DR: It is demonstrated here that the uterine glands remain active until at least wk 10 of pregnancy, and that their secretions are delivered freely into the placental intervillous space, demonstrating that they are an important source of nutrients during organogenesis, when metabolism is essentially anaerobic.
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Maternal arterial connections to the placental intervillous space during the first trimester of human pregnancy: the Boyd collection revisited.
TL;DR: The maternal circulation to the placenta must be extremely sluggish before the eighth week of pregnancy but will be gradually established over the next few weeks, and development of the human fetoplacental unit during most of the first trimester takes place in a low-oxygen environment.
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Evaluation of respiratory gases and acid-base gradients in human fetal fluids and uteroplacental tissue between 7 and 16 weeks' gestation
TL;DR: Evaluated changes in intrauterine gases and acid-base gradients inside the human fetoplacental unit at 7 to 16 weeks' gestation found that early human placental tissue develops in a physiologically low-oxygen environment compared with uterine tissue.
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Susceptibility of human placental syncytiotrophoblastic mitochondria to oxygen-mediated damage in relation to gestational age
TL;DR: An acute sensitivity of first trimester placenta syncytiotrophoblast to oxygen-mediated damage is indicated and mitochondrial activity loss is identified as an early event in this process.