Agnieszka Piszczek

TL;DR: A Cre-driver mouse line that expresses Cre-recombinase from the locus of the sensory neuron specific gene Advillin will be a powerful tool for targeting peripheral neurons in future investigations.

TL;DR: It is shown that recombinant human insulin‐like growth factor‐1 (rhIGF‐1) stimulates proliferation of both human and mouse regulatory T (Treg) cells in vitro and when delivered systemically via continuous minipump, it halts autoimmune disease progression in mouse models of type 1 diabetes and multiple sclerosis in vivo.

TL;DR: Decellularized mouse tissue is used to show that the E-peptides facilitate in vitro binding of murine IGF-1 to the extracellular matrix (ECM) with varying affinities, offering a potentially powerful way to tether IGF- 1 and other therapeutic proteins to the site of synthesis and/or administration.

TL;DR: A novel Cre-dependent inducible allele of Htr1a is used in mice to show that expression of HTr1a in cortical principal neurons is sufficient to modulate anxiety, and these results support a hetero/auto-receptor interaction model for Htr 1a function in anxiety.

TL;DR: Testing the hypothesis that Htr1a auto‐receptors are necessary, but not sufficient, to modulate anxiety in knockout mice shows that, in the absence of Htr 1a hetero‐receptorors, auto-receptor are unable to have an impact on anxiety.