A
Ai Hong Ma
Researcher at University of California, Davis
Publications - 24
Citations - 2272
Ai Hong Ma is an academic researcher from University of California, Davis. The author has contributed to research in topics: Prostate cancer & Androgen receptor. The author has an hindex of 17, co-authored 24 publications receiving 2047 citations.
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Journal ArticleDOI
An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells.
Xu Bao Shi,Lingru Xue,Joy C. Yang,Ai Hong Ma,Jianjun Zhao,Ma Xu,Clifford G. Tepper,Christopher P. Evans,Hsing Jien Kung,Ralph W deVere White +9 more
TL;DR: Differential expression of miR-125b is found in androgen-dependent and independent CaP cells, as well as in benign and malignant prostate tissues, and transfection of synthetic miR -125b stimulated androgens-independent growth ofCaP cells and down-regulated the expression of Bak1.
Journal Article
Characterization of a Novel Androgen Receptor Mutation in a Relapsed CWR22 Prostate Cancer Xenograft and Cell Line
Clifford G. Tepper,David L. Boucher,Philip E. Ryan,Ai Hong Ma,Liang Xia,Liang Xia,Li Fen Lee,Thomas G. Pretlow,Hsing Jien Kung +8 more
TL;DR: The CWR22Rv1 cell line displays both androgens-responsive and androgen-insensitive features due, at least in part, to a novel insertional mutation of the AR.
Journal ArticleDOI
Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy
Minan Wang,Li Chin Yao,Mingshan Cheng,Danying Cai,Jan Martinek,Chong-Xian Pan,Wei Shi,Ai Hong Ma,Ralph W deVere White,Susan D. Airhart,Edison T. Liu,Jacques Banchereau,Michael A. Brehm,Dale L. Greiner,Leonard D. Shultz,Karolina Palucka,James G. Keck +16 more
TL;DR: Tumor‐bearing HuNSG mice may represent an important, new model for preclinical immunotherapy research, and inhibition of tumor growth was dependent on hCD8+T cells, as demonstrated by antibody‐mediated depletion.
Journal ArticleDOI
miR-125b promotes growth of prostate cancer xenograft tumor through targeting pro-apoptotic genes.
TL;DR: This study determined the influence of miR‐125b on the pathogenesis of CaP and demonstrated that miR-125b stimulated the growth of prostate cancer (CaP) cells.
Journal Article
Functional analysis of 44 mutant androgen receptors from human prostate cancer.
TL;DR: This work generated 44 androgen receptor mutants that have been identified in human prostate cancer and used a colorimetric yeast reporter assay to analyze their transactivational activities in response to seven different ligands, finding five of 20 gain-of-function mutants had promiscuous activity, being transactivated by non-androgens.