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Aiala Lorente-Trigos
Researcher at University of Geneva
Publications - 3
Citations - 435
Aiala Lorente-Trigos is an academic researcher from University of Geneva. The author has contributed to research in topics: Cancer & Wnt signaling pathway. The author has an hindex of 3, co-authored 3 publications receiving 384 citations.
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Journal ArticleDOI
NANOG regulates glioma stem cells and is essential in vivo acting in a cross‐functional network with GLI1 and p53
Marie Zbinden,Arnaud Duquet,Aiala Lorente-Trigos,Sandra-Nadia Ngwabyt,Isabel Borges,Ariel Ruiz i Altaba +5 more
TL;DR: The data establish NANOG as a novel HH‐GLI mediator essential for GBMs and propose that this function is conserved and that tumour growth and stem cell behaviour rely on the status of a functional GLI1‐NANOG‐p53 network.
Journal ArticleDOI
The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT‐TCF pathway responses in human cancer
Alice Melotti,Christophe Mas,Monika Kuciak,Aiala Lorente-Trigos,Isabel Borges,Ariel Ruiz i Altaba +5 more
TL;DR: It is reported that Ivermectin inhibits the expression of WNT‐TCF targets, mimicking dnTCF, and that its low concentration effects are rescued by direct activation by TCFVP16, indicating its action involves protein phosphatases.
Journal ArticleDOI
BMP Signaling Promotes the Growth of Primary Human Colon Carcinomas in vivo
TL;DR: The possibility that blockade of BMP signaling might have beneficial effects against at least a subset of advanced colon cancers is raised.