A
Aideen E. Ryan
Researcher at National University of Ireland, Galway
Publications - 63
Citations - 2918
Aideen E. Ryan is an academic researcher from National University of Ireland, Galway. The author has contributed to research in topics: Mesenchymal stem cell & Immune system. The author has an hindex of 24, co-authored 59 publications receiving 2228 citations. Previous affiliations of Aideen E. Ryan include National University of Ireland.
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Journal ArticleDOI
Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications
TL;DR: Current knowledge related to the potential use of MSC-derived EVs in various diseases is reviewed and the promising future for EVs as an alternative, cell-free therapy is discussed.
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Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat
Gerard F. Curley,Mairead Hayes,Bilal Ansari,Georgina Shaw,Aideen E. Ryan,Frank Barry,Timothy O'Brien,Daniel O'Toole,John G. Laffey +8 more
TL;DR: MSC therapy enhances lung repair following VILI via a paracrine mechanism that may be keratinocyte growth factor-dependent and not seen with non-stem cells (ie, rat fibroblasts).
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Anti-donor immune responses elicited by allogeneic mesenchymal stem cells: what have we learned so far?
Matthew D. Griffin,Aideen E. Ryan,Senthilkumar Alagesan,Paul Lohan,Oliver Treacy,Thomas Ritter +5 more
TL;DR: The concept of the immune privileged nature of allo‐MSCs should be reconsidered and that the range and clinical implications of anti‐donor immune responses elicited by allo-MSCs be more precisely studied in human and animal recipients.
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Effects of intratracheal mesenchymal stromal cell therapy during recovery and resolution after ventilator-induced lung injury.
Gerard F. Curley,Bilal Ansari,Mairead Hayes,James Devaney,Claire Masterson,Aideen E. Ryan,Frank Barry,Timothy O'Brien,Daniel O’ Toole,John G. Laffey +9 more
TL;DR: Intratracheal MSC therapy enhanced recovery after ventilation-induced lung injury via a paracrine mechanism, and was as effective as intravenous MSC Therapy.
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Anti-Donor Immune Responses Elicited by Allogeneic Mesenchymal Stem Cells and Their Extracellular Vesicles: Are We Still Learning?
Paul Lohan,Oliver Treacy,Matthew D. Griffin,Matthew D. Griffin,Thomas Ritter,Thomas Ritter,Aideen E. Ryan +6 more
TL;DR: Recent published studies using non-manipulated, inflammatory molecule-activated (licensed) and differentiated allogeneic MSC, as well as MSC extracellular vesicles focusing on the immune responses to these cells are reviewed to determine whether or not such responses have an impact on allogenei MSC-mediated safety and efficacy.