Aihong Yang

TL;DR: Kinetic analysis and molecular docking studies indicated that these xanthone derivatives targeted both the catalytically active site (CAS) and the peripheral anion site (PAS) of AChE, and all derivatives showed higher anti-oxidative activity than vitamin C.

TL;DR: In this article, a series of naringenin derivatives were designed and synthesized as multifunctional anti-Alzheimer's disease (AD) agents, and the results showed that these derivatives displayed moderate-to-good acetylcholinesterase (AChE) and butyrylcholine choline (BuChE), inhibitory activities at the micromolar range (IC50, 12.91-62.52μm for AChE and 0.094-13.72-μM for BuChE).

TL;DR: In this paper, the multi-target-directed ligand (MTDL) based on "one molecule, multiple targets" has been studied to regulate multiple biological targets at the same time, which has shown higher efficacy, better safety.

TL;DR: Results suggested that 1‐hydroxy‐3‐[2‐(pyrrolidin‐1‐yl)ethoxy]‐9H‐xanthen‐9‐one was promising AChEI with metal chelating ability and antioxidant ability for the further investigation.

TL;DR: Four new emodin derivatives which inhibit Alzheimer's disease were designed and the related activities such as cholinesterase inhibitor, anti-oxidant and metal chelator were evaluated, and these derivatives have multi-factor anti-Alzheimer's disease activities.