Biomedical scientists use chemistry-driven processes found in nature as an inspiration to design biomaterials as promising diagnostic tools, therapeutic solutions, or tissue substitutes. While substantial consideration is devoted to the design and validation of biomaterials, the nature of their interactions with the surrounding biological microenvironment is commonly neglected. This gap of knowledge could be owing to our poor understanding of biochemical signaling pathways, lack of reliable techniques for designing biomaterials with optimal physicochemical properties, and/or poor stability of biomaterial properties after implantation. The success of host responses to biomaterials, known as biocompatibility, depends on chemical principles as the root of both cell signaling pathways in the body and how the biomaterial surface is designed. Most of the current review papers have discussed chemical engineering and biological principles of designing biomaterials as separate topics, which has resulted in neglecting the main role of chemistry in this field. In this review, we discuss biocompatibility in the context of chemistry, what it is and how to assess it, while describing contributions from both biochemical cues and biomaterials as well as the means of harmonizing them. We address both biochemical signal-transduction pathways and engineering principles of designing a biomaterial with an emphasis on its surface physicochemistry. As we aim to show the role of chemistry in the crosstalk between the surface physicochemical properties and body responses, we concisely highlight the main biochemical signal-transduction pathways involved in the biocompatibility complex. Finally, we discuss the progress and challenges associated with the current strategies used for improving the chemical and physical interactions between cells and biomaterial surface.

/pdf/biological-responses-to-physicochemical-properties-of-3i6vn14043.pdf

Biological responses to physicochemical properties of biomaterial surface.

Advancements in MXene-Polymer composites for various biomedical applications

Optical techniques used in medical diagnosis, surgery, and therapy require efficient and flexible delivery of light from light sources to target tissues. While this need is currently fulfilled by glass and plastic optical fibers, recent emergence of biointegrated approaches, such as optogenetics and implanted devices, call for novel waveguides with certain biophysical and biocompatible properties and desirable shapes beyond what the conventional optical fibers can offer. To this end, exploratory efforts have begun to harness various transparent biomaterials to develop waveguides that can serve existing applications better and enable new applications in future photomedicine. Here, we review the recent progress in this new area of research for developing biomaterial-based optical waveguides. We begin with a survey of biological light-guiding structures found in plants and animals, a source of inspiration for biomaterial photonics engineering. We describe natural and synthetic polymers and hydrogels that offer appropriate optical properties, biocompatibility, biodegradability, and mechanical flexibility have been exploited for light-guiding applications. Finally, we briefly discuss perspectives on biomedical applications that may benefit from the unique properties and functionalities of light-guiding biomaterials.

Light-Guiding Biomaterials for Biomedical Applications.

INTRODUCTION- BIOMATERIALS- CERAMIC MATERIALS FOR PROSTHETIC AND RESTORATION USE- CERAMIC MATERIALS FOR ORTHODONTIC USE- MICROSTRUCTURE OF CERAMIC MATERIALS- MECHANICAL BEHAVIOR OF CERAMIC MATERIALS- DENTAL ALUMINA: MICROSTRUCTURE AND PROPERTIES- DEGRADATION OF DENTAL CERAMICS

Dental Ceramics : Microstructure, Properties and Degradation

The reconstruction or repair of oral and maxillofacial functionalities and aesthetics is a priority for patients affected by tooth loss, congenital defects, trauma deformities, or various dental diseases. Therefore, in dental medicine, tissue reconstruction represents a major interest in oral and maxillofacial surgery, periodontics, orthodontics, endodontics, and even daily clinical practice. The current clinical approaches involve a vast array of techniques ranging from the traditional use of tissue grafts to the most innovative regenerative procedures, such as tissue engineering. In recent decades, a wide range of both artificial and natural biomaterials and scaffolds, genes, stem cells isolated from the mouth area (dental follicle, deciduous teeth, periodontal ligament, dental pulp, salivary glands, and adipose tissue), and various growth factors have been tested in tissue engineering approaches in dentistry, with many being proven successful. However, to fully eliminate the problems of traditional bone and tissue reconstruction in dentistry, continuous research is needed. Based on a recent literature review, this paper creates a picture of current innovative strategies applying dental stem cells for tissue regeneration in different dental fields and maxillofacial surgery, and offers detailed information regarding the available scientific data and practical applications.

https://www.mdpi.com/1996-1944/13/22/5303/pdf

Advanced Biomaterials and Techniques for Oral Tissue Engineering and Regeneration-A Review.

OBJECTIVE: To determine the shear bond strength of orthodontic brackets using color change adhesives that are supposed to aid in removing excess of bonding material and compare them to a traditional adhesive. METHODS: Ninety metallic and ninety ceramic brackets were bonded to bovine incisors using two color change adhesives and a regular one. A tensile stress was applied by a universal testing machine. The teeth were observed in a microscope after debonding in order to determine the Adhesive Remnant Index (ARI). RESULTS: The statistical analysis (ANOVA, Tukey, and Kruskall-Wallis tests) demonstrated that the mean bond strength presented no difference when metallic and ceramic brackets were compared but the bond resistance values were significantly different for the three adhesives used. The most common ARI outcome was the entire adhesive remaining on the enamel. CONCLUSIONS: The bond strength was similar for metallic and ceramic brackets when the same adhesive system was used. ARI scores demonstrated that bonding with these adhesives is safe even when ceramic brackets were used. On the other hand, bond strength was too low for orthodontic purposes when Ortho Lite Cure was used.

/pdf/shear-bond-strength-of-metallic-and-ceramic-brackets-using-3yd86m3c33.pdf

Shear bond strength of metallic and ceramic brackets using color change adhesives

Mechanical behavior of alumina and alumina-feldspar based ceramics in an acetic acid (4%) environment

Dental Ceramics. Microstructure, Properties and Degradation Series: Topics in Mining, Metallurgy and Materials Engineering - Libros de Medicina - Odontologia - 51,95

Dental Ceramics. Microstructure, Properties and Degradation Series: Topics in Mining, Metallurgy and Materials Engineering

Tienda online donde Comprar Dental Ceramics. Microstructure, Properties and Degradation Series: Topics in Mining, Metallurgy and Materials Engineering al precio 54,55 € de Carlos P. Bergmann | Aisha Stumpf, tienda de Libros de Medicina, Libros de Odontologia - Odontologia

Comprar Dental Ceramics. Microstructure, Properties and Degradation Series: Topics in Mining, Metallurgy and Materials Engineering | Carlos P. Bergmann | 9783642382239 | Springer

Aisha Stumpf

Papers

Dental Ceramics : Microstructure, Properties and Degradation

Shear bond strength of metallic and ceramic brackets using color change adhesives

Mechanical behavior of alumina and alumina-feldspar based ceramics in an acetic acid (4%) environment

Dental Ceramics. Microstructure, Properties and Degradation Series: Topics in Mining, Metallurgy and Materials Engineering

Comprar Dental Ceramics. Microstructure, Properties and Degradation Series: Topics in Mining, Metallurgy and Materials Engineering | Carlos P. Bergmann | 9783642382239 | Springer