A
Akio Adachi
Researcher at Kansai Medical University
Publications - 254
Citations - 10148
Akio Adachi is an academic researcher from Kansai Medical University. The author has contributed to research in topics: Virus & Viral replication. The author has an hindex of 47, co-authored 252 publications receiving 9918 citations. Previous affiliations of Akio Adachi include National Institutes of Health & Kyoto University.
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Journal ArticleDOI
Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone.
Akio Adachi,Howard E. Gendelman,Scott Koenig,Thomas M. Folks,Ronald Willey,Arnold B. Rabson,M A Martin +6 more
TL;DR: In this paper, an infectious molecular clone of acquired immunodeficiency syndrome-associated retrovirus was constructed, and upon transfection, this clone directed the production of infectious virus particles in a wide variety of cells in addition to human T4 cells.
Journal ArticleDOI
Trans-activation of the human immunodeficiency virus long terminal repeat sequence by DNA viruses.
Howard E. Gendelman,William C. Phelps,Lionel Feigenbaum,Jeffrey M. Ostrove,Akio Adachi,Peter M. Howley,George Khoury,Harold S. Ginsberg,Malcolm A. Martin +8 more
TL;DR: In conclusion, cotransfection of cells by HIV and some DNA viruses can stimulate the expression of HIV, and more-than-additive effects were observed at both the RNA and protein levels when tat plus type 1 herpes simplex virus DNAs or tatplus JC virus DN as were transfected into cells with the HIV LTR-CAT plasmid.
Journal ArticleDOI
Generation of a chimeric human and simian immunodeficiency virus infectious to monkey peripheral blood mononuclear cells.
TL;DR: Western immunoblotting analysis of the replicating chimera in PBMC confirmed the hybrid nature of the virus and suggested that the sequence important for macaque cell tropism lies within the LTR, gag, pol, and/or vif sequences of the SIVMAC genome.
Journal ArticleDOI
Productive, persistent infection of human colorectal cell lines with human immunodeficiency virus.
Akio Adachi,Scott Koenig,Howard E. Gendelman,Daryl Daugherty,Sebastiano Gattoni-Celli,Anthony S. Fauci,M A Martin +6 more
TL;DR: A persistently infected colon carcinoma cell line was established that continued to produce progeny human immunodeficiency virus for more than 10 weeks postinfection.
Journal ArticleDOI
Cell-dependent requirement of human immunodeficiency virus type 1 Vif protein for maturation of virus particles.
TL;DR: A highly sensitive single-round infection assay using a bacterial chloramphenicol acetyltransferase was developed to analyze an early stage of human immunodeficiency virus type 1 replication and concluded that the Vif protein acts through modulation of the Env protein in the virions, directly or indirectly, to enhance viral infectivity in a certain cell type.