Showing papers by "Albert de la Chapelle published in 1977"
TL;DR: In this paper, an attempt was made to assess the epidemiologic and genetic factors contributing to the adverse drug effect in the case of agranulocytosis and granulocytopenia.
Abstract: An epidemic of agranulocytosis and granulocytopenia occurred in 1975 in conjunction with clozapine treatment of mental patients in Finland. An attempt was made to assess the epidemiologic and genetic factors contributing to the adverse drug effect. The estimated incidence rate in Finland was 2.1/1000 patient-months. This figure could not be compared with rates from other countries because of the inexact nature of the figures reported so far. All 16 cases occurred in seven hospitals in southwestern Finland, whereas the overall hospital net use of the drug was geographically evenly distributed. The difference between the observed and the proportionally expected incidence of cases amongst the hospitals where clozapine was used was statistically significant. The average consumption of the drug did not differ between the hospitals where cases occurred and those where no definite cases could be diagnosed. Six-generation pedigree analyses failed to reveal significant parental consanguinity or genetic kinship between probands. Neither did the birth places of the ancestors of the probands disclose a typical isolate pattern. In conclusion, the cases appeared to be confined to a few hospitals in southwestern Finland. Although a genetic factor is not excluded, we found no evidence in support of a genetic mechanism.
159 citations
TL;DR: The results from a study of neutrophil function in five patients with monosomy-7 seem to suggest an association between this chromosome abnormality and defective chemotaxis.
Abstract: CELLULAR defects of chemotaxis are rare disorders1. Little is known about the cellular mechanisms of the chemotactic response, and in most cases the nature of the defect remains obscure. Singh et al. have reported defective chemotaxis in association with a chromosomal abnormality2. In their patient, bone marrow cells were tetraploid. In most cells a chromosome 16 was missing and there was an extra C-group chromosome. We investigated neutrophil granulocyte function in haematological disorders. Our results from a study of neutrophil function in five patients with monosomy-7 seem to suggest an association between this chromosome abnormality and defective chemotaxis.
68 citations