Objective. —To review the scientific literature on the alterations in the senses of taste and smell in the elderly, including causes, diagnosis, prognosis, and treatment. Data Sources. —Original reports and reviews obtained through MEDLINE searches from 1966 through June 1997 using the MeSH headings of "taste," "taste buds," "taste disorders," "taste thresholds," "smell," "odors," "aged," and "aging." Articles frequently cited in reference lists were also included. Study Selection. —All articles were reviewed, tabulated, and summarized. Data Extraction. —Criteria for extraction included data quality and validity, statistical treatment of the data, venue of publication, and relevance to clinical care. Conclusion. —Losses of taste and smell are common in the elderly and result from normal aging, certain disease states (especially Alzheimer disease), medications, surgical interventions, and environmental exposure. Deficits in these chemical senses cannot only reduce the pleasure and comfort from food, but represent risk factors for nutritional and immune deficiencies as well as adherence to specific dietary regimens. Chemosensory decrements can lead to food poisoning or over-exposure to environmentally hazardous chemicals that are otherwise detectable by taste and smell. Use of flavor-enhanced food can increase enjoyment of food and have a positive effect on food intake and immune status.

https://jamanetwork.com/journals/JAMA/articlepdf/418447/jama_278_16_042.pdf

Taste and Smell Losses in Normal Aging and Disease

Publisher Summary This chapter discusses the selection of food by rats, humans, and other animals, and focuses on the complex problems, especially in food recognition and choice, in the omnivores or generalists. Food selection implies food ingestion. Food ingestion implies the presence of food. Therefore, background for the study of food selection includes the food search process: search images and search mechanisms for finding appropriate food stimuli in the environment. Honey bees provide fine examples of a highly developed food search system. Food selection also implies the ability to obtain or capture food, and to assimilate it, for which many often exotic mechanisms have been evolved. Given the presence of potential food, ingestion then usually depends on an internal state or detector indicating a “need” for the particular food or class of foods, and recognition of the potential food as food. Omnivores, such as rats and humans, faced with an enormous number of potential foods, must choose wisely. They are always in danger of eating something harmful or eating too much of a good thing. Although there are some helpful internal mechanisms, such as poison detoxification, nutrient biosynthesis, and nutrient storage, the major share of the burden for maintaining nutritional balance must out of necessity come from incorporation of appropriate nutrients in the environment and, hence, behavior. The most striking parallel between human and rat feeding is in the neophobia seen in both. The chapter discusses the multiple determinants of food selection in man that are divided into biological factors and effects of individual experience, on one hand, and cultural influences, on the other.

The Selection of Foods by Rats, Humans, and Other Animals

Is the bitter rejection response always adaptive

Effective R&D and strict quality control of a broad range of foods, beverages, and pharmaceutical products require objective taste evaluation. Advanced taste sensors using artificial-lipid membranes have been developed based on concepts of global selectivity and high correlation with human sensory score. These sensors respond similarly to similar basic tastes, which they quantify with high correlations to sensory score. Using these unique properties, these sensors can quantify the basic tastes of saltiness, sourness, bitterness, umami, astringency and richness without multivariate analysis or artificial neural networks. This review describes all aspects of these taste sensors based on artificial lipid, ranging from the response principle and optimal design methods to applications in the food, beverage, and pharmaceutical markets.

Advanced Taste Sensors Based on Artificial Lipids with Global Selectivity to Basic Taste Qualities and High Correlation to Sensory Scores

1. In recordings made from 3,120 single neurons, a secondary cortical taste area was found in the caudolateral part of the orbitofrontal cortex of the cynomolgus macaque monkey, Macaca fascicularis...

https://www.oxcns.org/papers/141_Rolls+Yaxley+90.pdf

Albert Theodor Poffenberger

Papers

The Sense of Taste