A
Alberto A. Ghini
Researcher at Facultad de Ciencias Exactas y Naturales
Publications - 23
Citations - 392
Alberto A. Ghini is an academic researcher from Facultad de Ciencias Exactas y Naturales. The author has contributed to research in topics: GABAA receptor & Receptor. The author has an hindex of 11, co-authored 23 publications receiving 380 citations.
Papers
More filters
Journal ArticleDOI
Differential Recruitment of Tetratricorpeptide Repeat Domain Immunophilins to the Mineralocorticoid Receptor Influences both Heat-Shock Protein 90-Dependent Retrotransport and Hormone-Dependent Transcriptional Activity†
TL;DR: The mineralocorticoid receptor (MR) forms oligomers with the heat-shock protein 90 (Hsp90) -based heterocomplex, which contains tetratricopeptide repeat (TPR) domain immunophilins (IMM) and the unknown biological role of IMMs was investigated.
Journal Article
Sodium-retaining activity of some natural and synthetic 21-deoxysteroids.
Gerardo Burton,Mario D. Galigniana,S De Lavallaz,A L Brachet-Cota,Eduardo M. Sproviero,Alberto A. Ghini,C.P. Lantos,María C. Damasco +7 more
TL;DR: All C21-deoxysteroids, except 11,19-oxidoprogesterone, exhibited parabolic log dose-response functions, indicating an effect that opposes renal sodium retention at high doses, and the latter correlation deteriorated upon incorporation of the affinity data for the three natural corticoids, but could be restored when the bindingData for the unpurified, corticosterone-binding globulin-containing stage of the receptors were considered.
Journal ArticleDOI
Differences in Nuclear Retention Characteristics of Agonist-Activated Glucocorticoid Receptor May Determine Specific Responses
Guillermo P. Vicent,Adali Pecci,Alberto A. Ghini,Graciela Piwien-Pilipuk,Mario D. Galigniana,Mario D. Galigniana +5 more
TL;DR: The dynamic exchange of liganded GR with chromatin is likely to have significant consequences for the observed pleiotropic physiological responses triggered by glucocorticoid ligands, not only in different tissues but also in the same cell type.
Journal ArticleDOI
Synthesis and GABAA receptor activity of 6-oxa-analogs of neurosteroids
Daniel Nicoletti,Alberto A. Ghini,Roman Furtmüller,Werner Sieghart,Robert H. Dodd,Gerardo Burton +5 more
TL;DR: Both steroids showed ca.
Journal ArticleDOI
13C NMR spectra of substituted indoles
TL;DR: In this article, the 13C chemical shifts for indole and ten indoles substituted at positions 1, 3 and/or 6 are reported, using specific deuterium labelling and selective proton decoupling.