Alec J. Murillo

TL;DR: It is found that fatty acids (FAs) compete with FcRn, revealing a clash between ligand binding and recycling, and that high-affinity HSA variants have significantly increased circulating half-lives in mice and monkeys.

TL;DR: Through a parallel approach of tracking product quality through fermentation and purification development, a robust process was designed to reduce the levels of product-related species, resulting in a product that was of equal quality and purity to that of small-scale development preparations.