The role of Bone Tissue Engineering in the field of Regenerative Medicine has been the topic of substantial research over the past two decades. Technological advances have improved orthopaedic implants and surgical techniques for bone reconstruction. However, improvements in surgical techniques to reconstruct bone have been limited by the paucity of autologous materials available and donor site morbidity. Recent advances in the development of biomaterials have provided attractive alternatives to bone grafting expanding the surgical options for restoring the form and function of injured bone. Specifically, novel bioactive (second generation) biomaterials have been developed that are characterised by controlled action and reaction to the host tissue environment, whilst exhibiting controlled chemical breakdown and resorption with an ultimate replacement by regenerating tissue. Future generations of biomaterials (third generation) are designed to be not only osteoconductive but also osteoinductive, i.e. to stimulate regeneration of host tissues by combining tissue engineering and in situ tissue regeneration methods with a focus on novel applications. These techniques will lead to novel possibilities for tissue regeneration and repair. At present, tissue engineered constructs that may find future use as bone grafts for complex skeletal defects, whether from post-traumatic, degenerative, neoplastic or congenital/developmental "origin" require osseous reconstruction to ensure structural and functional integrity. Engineering functional bone using combinations of cells, scaffolds and bioactive factors is a promising strategy and a particular feature for future development in the area of hybrid materials which are able to exhibit suitable biomimetic and mechanical properties. This review will discuss the state of the art in this field and what we can expect from future generations of bone regeneration concepts.

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Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective

Numerical simulation of the laser welding process in butt-joint specimens

Effects of welding speed, energy input and heat source distribution on temperature variations in butt joint welding

The main emphasis of this review is on thermal modelling and prediction of laser welding in metals. However as similar techniques are employed to model conventional welding processes such as arc, resistance and friction, as well as related processes such as alloying, cladding and surface hardening, part of this review is given over to the modelling of these processes where appropriate. The time frame of the review is up to the year 2002.

Thermal modelling of laser welding and related processes: a literature review

Prediction of welding distortion in butt joint of thin plates.

Finite-element prediction of distortion during gas metal arc welding using the shrinkage volume approach

• Musculoskeletal conditions are a major contributor to the burden of disease globally and their impact is predicted to increase. • Consistent with findings in other countries, the current standard of musculoskeletal education in Australian medical schools is inadequate to meet today's musculoskeletal care requirements. • A national multidisciplinary approach unifying the key musculoskeletal clinical and basic science disciplines has been adopted to provide clear, evidence-based education guidelines that are specifically aimed at priority musculoskeletal conditions; a direct link is therefore established between community health care needs and education at a national level. • This "top-down" approach provides the potential for a far more effective and efficient delivery of musculoskeletal education by allowing the identification of the key basic knowledge and skills required to achieve core competencies and by providing appropriate direction for students. • The Australian Core Competencies in Musculoskeletal Basic and Clinical Science are being developed for medical schools to incorporate into their curricula, with the ultimate aim of improving the standard of health care for Australians with musculoskeletal conditions.

Aleksander Bachorski

Papers

Finite-element prediction of distortion during gas metal arc welding using the shrinkage volume approach

Development of the Australian Core Competencies in Musculoskeletal Basic and Clinical Science project - phase 1.