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Aleksey Lomakin
Researcher at Massachusetts Institute of Technology
Publications - 74
Citations - 8913
Aleksey Lomakin is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Phase (matter) & Protein structure. The author has an hindex of 41, co-authored 74 publications receiving 8449 citations. Previous affiliations of Aleksey Lomakin include Brigham and Women's Hospital & United States Department of Veterans Affairs.
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Journal ArticleDOI
Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways.
Gal Bitan,Marina D. Kirkitadze,Aleksey Lomakin,Sabrina S. Vollers,George B. Benedek,David B. Teplow +5 more
TL;DR: In this article, photo-induced cross-linking of unmodified proteins (PICUP) was combined with size-exclusion chromatography, dynamic light scattering, circular dichroism spectroscopy, and electron microscopy to reveal the early assembly of Aβ40 and Aβ42.
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Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates.
Dominic M. Walsh,Dean M. Hartley,Yoko Kusumoto,Youcef Fezoui,Margaret M. Condron,Aleksey Lomakin,Aleksey Lomakin,George B. Benedek,Dennis J. Selkoe,David B. Teplow +9 more
TL;DR: Walsh et al. as discussed by the authors found that amyloid protofibrils are in equilibrium with low molecular weight Abeta (monomeric or dimeric) and have a secondary structure characteristic of Amyloid fibrils.
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On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants
TL;DR: The approach provides a powerful means for the quantitative assay of A beta fibrillogenesis and found that the surfactant n-dodecylhexaoxyethylene glycol monoether (C12E6) slowed nucleation and elongation of fibrils in a concentration-dependent manner.
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Kinetic theory of fibrillogenesis of amyloid β-protein
TL;DR: It is suggested that the method of QLS in combination with this theory can serve as a powerful tool for understanding the molecular factors that control Aβ plaque formation.
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Development of a Multimarker Assay for Early Detection of Ovarian Cancer
Zoya R. Yurkovetsky,Steven J. Skates,Aleksey Lomakin,Brian M. Nolen,Trenton C. Pulsipher,Francesmary Modugno,Jeffrey R. Marks,Andrew K. Godwin,Elieser Gorelik,Ian Jacobs,Usha Menon,Karen H. Lu,Donna Badgwell,Robert C. Bast,Anna Lokshin +14 more
TL;DR: A panel of CA-125, HE4, CEA, and VCAM-1, after additional validation, could serve as an initial stage in a screening strategy for epithelial ovarian cancer.