Fast screening method for the determination of angiotensin II receptor antagonists in human plasma by high-performance liquid chromatography with fluorimetric detection.

Neste trabalho sao apresentadas as definicoes dosparâmetros (seletividade, limites de deteccao equantificacao, exatidao, precisao, linearidade, graficoanalitico, sensibilidade e robustez) considerados nosprocessos de validacao de metodos analiticos. Aestrategia a ser adotada para a determinacao dessesparâmetros depende do proposito e da natureza dometodo. Exemplos sao apresentados para aavaliacao dos parâmetros no procedimento devalidacao. ANALYTICAL METHODS VALIDATION: STRATEGY AND DISCUSSION Abstract This paper presents the definitions of the parameters (selectivity, limits of detection and quantification, accuracy, precision,linearity, analytical graphic, sensitivity and ruggedness) considered on analytical methods validation procedures. The strategy to be adopted for determinations of these parameters depends on the purpose and the nature of the method.Some examples are presented for parameters evaluation in a validation procedure.

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Validação de métodos analíticos: estratégia e discussão

Simultaneous determination of valsartan and hydrochlorothiazide in tablets by first-derivative ultraviolet spectrophotometry and LC.

Comparison of UV- and second derivative-spectrophotometric and LC methods for the determination of valsartan in pharmaceutical formulation

Optimization and validation of a capillary zone electrophoretic method for the analysis of several angiotensin-II-receptor antagonists.

Development and validation of chiral high-performance liquid chromatographic methods for the quantitation of valsartan and of the tosylate of valinebenzyl ester.

Process for preparing 2-(2'-hydroxyphenyl)-benzotriazoles of the formula ##STR1## from 2-nitro-2'-hydroxyazobenzenes of the formula ##STR2## which comprises reducing a 2-nitro-2'-hydroxyazobenzene compound in a strongly basic medium in the presence of an aromatic dihydroxy or dioxo compound as catalyst and of an alcohol having more than one carbon atom. The 2-(2'-hydroxyphenyl)-benzotriazole compounds are known stabilizers for organic materials.

Novel process for preparation of benzotriazoles using aryldiols and quinones

Verfahren zur Herstellung von 2-(2'-Hydroxyphenyl)-benztriazolen der Formel A process for the preparation of 2- (2'-hydroxyphenyl) -benztriazolen of formula aus 2-Nitro-2'-hydroxyazobenzolen der Formel from 2-nitro-2'-hydroxyazobenzolen of formula dadurch geken-zeichnet, dass man eine 2-Nitro-2'-hydroxy- azobenzol-Verbindung in stark basischem Medium in Gegenwart einer aromatischen Didydroxy- oder Dioxo-Verbindung als Katalysator und eines Alkohols mit mehr als einem Kohlenstoffatom reduziert. characterized geken-characterized, that in the presence of an aromatic Didydroxy- or dioxo compound reducing a 2-nitro-2'-hydroxy-azobenzene compound in a strongly basic medium as catalyst and of an alcohol with more than one carbon atom. Die 2-(2'-Hydroxyphenyl)-benztriazol-Verbindungen sind bekannte Stabilisatoren fur organische Materialen. The 2- (2'-hydroxyphenyl) benzotriazole compounds are known stabilizers for organic materials.

Alexander Dr. Davatz

Papers

Development and validation of chiral high-performance liquid chromatographic methods for the quantitation of valsartan and of the tosylate of valinebenzyl ester.

Novel process for preparation of benzotriazoles using aryldiols and quinones

Process for the preparation of 2-arylbenzotriazoles