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Alexandra Gerogianni
Publications - 4
Citations - 303
Alexandra Gerogianni is an academic researcher. The author has contributed to research in topics: Complement system & Chemistry. The author has an hindex of 1, co-authored 1 publications receiving 294 citations.
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Journal ArticleDOI
Symptom Improvement in Lung Cancer Patients Treated With Erlotinib: Quality of Life Analysis of the National Cancer Institute of Canada Clinical Trials Group Study BR.21
Andrea Bezjak,Dongsheng Tu,Lesley Seymour,Gary M. Clark,Aleksandra Trajkovic,Mauro Zukin,Joseph Ayoub,Sergio Lago,Ronaldo A. Ribeiro,Alexandra Gerogianni,Arnold Cyjon,Jonathan Noble,Francis Laberge,Raymond T. T. Chan,David Fenton,Joachim von Pawel,Martin Reck,Frances A. Shepherd +17 more
TL;DR: Eerrlotinib not only improves survival in previously treated patients with NSCLC, but also improves tumor-related symptoms and important aspects of QOL.
Journal ArticleDOI
Heme Interferes With Complement Factor I-Dependent Regulation by Enhancing Alternative Pathway Activation
Alexandra Gerogianni,Jordan D. Dimitrov,Alessandra Zarantonello,Victoria Poillerat,Satheesh Chonat,Kerstin Sandholm,Karin E. McAdam,Kristina Nilsson Ekdahl,Tom Eirik Mollnes,Camilla Mohlin,Lubka T. Roumenina,Per H. Nilsson +11 more
TL;DR: A mechanistic explanation of how heme promotes uncontrolled complement alternative pathway amplification by interfering with the regulatory capacity of factor I is presented.
Journal ArticleDOI
Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood
Anne Landsem,Åse Emblem,Corinna Lau,Dorte Christiansen,Alexandra Gerogianni,Bård Ove Karlsen,Tom Eirik Mollnes,Per H. Nilsson,Ole-Lars Brekke +8 more
TL;DR: In this paper , the role of complement in platelet aggregation in Escherichia coli (E. coli)-induced human whole blood, using Multiplate® aggregometry, flow cytometry, and confocal microscopy was investigated.
Journal ArticleDOI
In vitro evaluation of iron oxide nanoparticle-induced thromboinflammatory response using a combined human whole blood and endothelial cell model
Alexandra Gerogianni,M. Bal,Camilla Mohlin,Trent M. Woodruff,John D. Lambris,Tom Eirik Mollnes,Dick J Sjöström,Per H. Nilsson +7 more
TL;DR: In this article , the authors investigated the effect of IONPs on complement activation at the C3 level in lepirudin anticoagulated whole blood and evaluated the therapeutic effect of applying complement inhibitors to limit adverse effects related to thromboinflammation.