Alfred M. Nyanda

TL;DR: The slow release of unmetabolized B(a)p from reproductive organs and the presence of reactive metabolites in these organs is a matter of concern as they could interfere with gonadal steroid synthesis and release and its regulatory role in gamete production, maturation and function of male animals in a continuous exposure paradigm.

TL;DR: The data suggest that inhaled BaP compromised fetal survival and consequently luteotropic activity in the exposed animals and plasma progesterone, estrogen, and prolactin concentrations declined as a result of subacute exposure of rats to BaP compared to controls.

TL;DR: The data suggest that sub-acute exposure to inhaled BaP contributes to reduced testosterone concentrations and consequently impaired epididymal function of exposed animals.

TL;DR: Results from this study suggest that a reduction in EC-SOD activity in hypertensive patients is not due to a down-regulation of the SOD3 gene (encoding EC- sOD) or deficiency in mineral cofactors, and the reduced EC- SOD activity might be at least partially responsible for the increased oxidative stress, as reflected by increased plasma nitrotyrosine and 8-isoprostane levels in hypertintensive subjects.

TL;DR: Findings of this study establish the relationship between bioavailability and the acute toxic effects of B a P observed in the laboratory at these high doses.