XI. STRATEGIES FOR IMPROVING DIABETES CARE D iabetes is a chronic illness that requires continuing medical care and patient self-management education to prevent acute complications and to reduce the risk of long-term complications. Diabetes care is complex and requires that many issues, beyond glycemic control, be addressed. A large body of evidence exists that supports a range of interventions to improve diabetes outcomes. These standards of care are intended to provide clinicians, patients, researchers, payors, and other interested individuals with the components of diabetes care, treatment goals, and tools to evaluate the quality of care. While individual preferences, comorbidities, and other patient factors may require modification of goals, targets that are desirable for most patients with diabetes are provided. These standards are not intended to preclude more extensive evaluation and management of the patient by other specialists as needed. For more detailed information, refer to Bode (Ed.): Medical Management of Type 1 Diabetes (1), Burant (Ed): Medical Management of Type 2 Diabetes (2), and Klingensmith (Ed): Intensive Diabetes Management (3). The recommendations included are diagnostic and therapeutic actions that are known or believed to favorably affect health outcomes of patients with diabetes. A grading system (Table 1), developed by the American Diabetes Association (ADA) and modeled after existing methods, was utilized to clarify and codify the evidence that forms the basis for the recommendations. The level of evidence that supports each recommendation is listed after each recommendation using the letters A, B, C, or E.

Standards of Medical Care in Diabetes

Introduction, K. Husnu Can Bas,er and G. Buchbauer History and Sources of Essential Oil Research, K.-H. Kubeczka Sources of Essential Oils, C. Franz and J. Novak Production of Essential Oils, E. Schmidt Chemistry of Essential Oils, C. Sell Analysis of Essential Oils, B. d'Acampora Zellner, P. Dugo, G. Dugo, and L. Mondello Safety Evaluation of Essential Oils: A Constituent-Based Approach, T.B. Adams and S.V. Taylor Metabolism of Terpenoids in Animal Models and Humans, W. Jager Biological Activities of Essential Oils, G. Buchbauer Effects of Essential Oils in the Central Nervous System Part I: Central Nervous System Effects of Essential Oils in Humans, E. Heuberger Part II: Psychopharmacology of Essential Oils, D. Savio Nunes, V. de Moura Linck, A. Lourenco da Silva, M. Figueiro, and E. Elisabetsky Phytotherapeutic Uses of Essential Oils, B. Harris In Vitro Antimicrobial Activities of Essential Oils Monographed in the European Pharmacopoeia 6th Edition, A. Pauli and H. Schilcher Aromatherapy with Essential Oils, M. Lis-Balchin Biotransformation of Monoterpenoids by Microorganisms, Insects, and Mammals, Y. Noma and Y. Asakawa Biotransformation of Sesquiterpenoids, Ionones, Damascones, Adamantanes, and Aromatic Compounds by Green Algae, Fungi, and Mammals, Y. Asakawa and Y. Noma Industrial Uses of Essential Oils, W.S. Brud Encapsulation and Other Programmed Release Techniques for Essential Oils and Volatile Terpenes, J. Karlsen Aroma-Vital Cuisine, M.M. Kettenring and L.M. Vucemilovic Essential Oils Used in Veterinary Medicine, K. Husnu Can Ba,ser and C. Franz Trade of Essential Oils, H. Bovill Storage and Transport of Essential Oils, K.-D. Protzen Recent EU Legislation on Flavors and Fragrances and its Impact on Essential Oils, J.C.R. Demyttenaere Index

Handbook of Essential Oils : Science, Technology, and Applications

Potatoes, members of the Solanaceae plant family, serve as major, inexpensive low-fat food sources providing energy (starch), high-quality protein, fiber, and vitamins. Potatoes also produce biologically active secondary metabolites, which may have both adverse and beneficial effects in the diet. These include glycoalkaloids, calystegine alkaloids, protease inhibitors, lectins, phenolic compounds, and chlorophyll. Because glycoalkaloids are reported to be involved in host-plant resistance and to have a variety of adverse as well as beneficial effects in cells, animals, and humans, a need exists to develop a clearer understanding of their roles both in the plant and in the diet. To contribute to this effort, this integrated review presents data on the (a) history of glycoalkaloids; (b) glycoalkaloid content in different parts of the potato plant, in processed potato products, and in wild, transgenic, and organic potatoes; (c) biosynthesis, inheritance, plant molecular biology, and glycoalkaloid−plant phyto...

Potato Glycoalkaloids and Metabolites: Roles in the Plant and in the Diet

Essential oils for the development of eco-friendly mosquito larvicides: A review

This review provides an updated overview of the most important applications of supercritical fluids in the extraction of bioactive compounds from plant matrices The main factors influencing the extraction yields, solubility, and manufacturing costs are described Aspects concerning the operational processing in the extraction and fractionation are also discussed The data compiled herein are focused on the extraction of essential oils, phenolic compounds, carotenoids, tocopherols, and tocotrienols

Supercritical Fluid Extraction of Bioactive Compounds: Fundamentals, Applications and Economic Perspectives

Origanum majorana L. (Lamiaceae) is a plant that is used in gastronomy and natural medicine. The plant material used in this study was collected at San Isidro de Apartaderos, Merida State. A yield of 0.6% of essential oil was obtained by hydro-distillation using a Clevenger trap. The main constituents found were: cis-sabinene hydrate (30.2%), terpinen-4-ol (28.8%), γ-terpinene (7.2%), α-terpineol (6.9%), trans-sabinene hydrate (4.4%), linalyl acetate (3.8%), and α-terpinene (3.6%). The essential oil was also fractionated over a silica gel dry column. Two main fractions were isolated, the first containing 67.6% of cis-sabinene hydrate and the second 72.8% of terpinen-4-ol. The antibacterial activity of the oil was determined using the agar diffusion method and it was found that it was active against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Klebsiella pneumoniae. Antibacterial activity of the fractions obtained by dry column chromatography was also tested. It was found th...

Chemical Composition and Antibacterial Activity of Origanum majorana L. Essential Oil from the Venezuelan Andes

Eryngium foetidum is a perennial herb native to tropical America whose leaves are used as food seasoning. The aerial parts of this plant were hydrodistilled and the essential oil was collected in a Clevenger-type trap. The oil was analyzed by GC and GC/MS. The main constituents were 2,4,5-trimethyl-benzaldehyde (27.7%), (E)-2-dodecenal (27.5%), carotol (8.8%), 3-dodecenal (5.2%) and γ-terpinene (3.8%).

Composition of the Essential Oil from the Leaves of Eryngium foetidum L. from the Venezuelan Andes

Commercial ethoxylated alkylphenol surfactants are always a mixture of oligomers with different ethylene oxide number (EON). The different oligomers can be separated by various HPLC techniques. Isocratic mode with mixed solvent on silica column allows to separate oligomers up to EON = 10; gradient programming moves the limit up to EON = 15. For higher EON values (up to 25) a NH2 column has to be used, either with isocratic or gradient mode. Applications to the analysis of microemulsion systems and to the separation of tributyl phenol ethoxylates are discussed. Extreme separation of wide range EON distribution is attained with two columns (Si and NH2) in series, and a solvent programming.

Optimization of HPLC Conditions to Analyze Widely Distributed Ethoxylated Alkylphenol Surfactants

The essential oil of Satureja brownei (SW.) Briq., was studied by GC and GC–MS. A yield of 0.12% of oil (v/w) was obtained. The main constituents found were pulegone (64.3%), menthone (20.2%), isomenthone (3.4%) and isopulegone (2.4%). Copyright © 2000 John Wiley & Sons, Ltd.

Composition of the essential oil of Satureja brownei (SW.) Briq. from Venezuela

New extended anionic surfactants with a carboxylate or sulfate polar head were synthesized from polypropoxylated alcohols, and their structures were confirmed by 1H and 13C nuclear magnetic resonance analysis. The extended surfactant critical micelle concentration was found to decrease with the length of the polypropylene glycol spacer. Surfactants containing a diethylene glycol link to the head group exhibited a higher critical micelle concentration than did their nondiethoxylated homologs.

Alfredo Usubillaga

Papers

Chemical Composition and Antibacterial Activity of Origanum majorana L. Essential Oil from the Venezuelan Andes

Composition of the Essential Oil from the Leaves of Eryngium foetidum L. from the Venezuelan Andes

Optimization of HPLC Conditions to Analyze Widely Distributed Ethoxylated Alkylphenol Surfactants

Composition of the essential oil of Satureja brownei (SW.) Briq. from Venezuela

Synthesis of new extended surfactants containing a carboxylate or sulfate polar group