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Alicia M. Viloria Petit
Researcher at University of Toronto
Publications - 1
Citations - 881
Alicia M. Viloria Petit is an academic researcher from University of Toronto. The author has contributed to research in topics: Receptor tyrosine kinase & Vascular endothelial growth factor A. The author has an hindex of 1, co-authored 1 publications receiving 867 citations.
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Journal Article
Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors.
Alicia M. Viloria Petit,Janusz Rak,Mien Chie Hung,Patricia Rockwell,Neil I. Goldstein,Brian M. Fendly,Robert S. Kerbel +6 more
TL;DR: Therapeutic disruption of EGFR or ErbB2/neu protein function in vivo may result in partial suppression of angiogenesis, a feature that could enhance the therapeutic index of such agents in vivo and endow them with anti-tumor effects, the magnitude of which may be out of proportion with their observed cytostatic effects in monolayer tissue culture.