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Alison Pedley
Researcher at Merck & Co.
Publications - 56
Citations - 3057
Alison Pedley is an academic researcher from Merck & Co.. The author has contributed to research in topics: Framingham Heart Study & Adipose tissue. The author has an hindex of 24, co-authored 51 publications receiving 2277 citations. Previous affiliations of Alison Pedley include National Institutes of Health & Brigham and Women's Hospital.
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Journal ArticleDOI
Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection
Mark H. Wilcox,Dale N. Gerding,Ian R. Poxton,Ciaran P. Kelly,Richard Nathan,Thomas Birch,Oliver A. Cornely,Galia Rahav,Emilio Bouza,Christine H. Lee,Grant Jenkin,Werner Jensen,You-Sun Kim,Jun-ichi Yoshida,Lori Gabryelski,Alison Pedley,Karen Eves,Robert W. Tipping,Dalya Guris,Nicholas A. Kartsonis,Mary Beth Dorr +20 more
TL;DR: Among participants receiving antibiotic treatment for primary or recurrent C. difficile infection, bezlotoxumab was associated with a substantially lower rate of recurrent infection than placebo and had a safety profile similar to that of placebo.
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The ratio of visceral to subcutaneous fat, a metric of body fat distribution, is a unique correlate of cardiometabolic risk
Bernhard M. Kaess,Alison Pedley,Joseph M. Massaro,Joanne M. Murabito,Udo Hoffmann,Caroline S. Fox +5 more
TL;DR: VAT/SAT ratio is a correlate of cardiometabolic risk, above and beyond BMI and VAT, and the propensity to store fat viscerally versus subcutaneously may be a unique risk factor independent of absolute fat volumes.
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Association between visceral and subcutaneous adipose depots and incident cardiovascular disease risk factors.
TL;DR: It is suggested that both volume and quality of VAT and SAT contribute to metabolic risk, and VAT volume and SAT volume are associated with incident metabolic risk factors beyond overall adiposity.
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Visceral and subcutaneous fat quality and cardiometabolic risk.
Klara J. Rosenquist,Alison Pedley,Joseph M. Massaro,Kate E. Therkelsen,Joanne M. Murabito,Udo Hoffmann,Caroline S. Fox,Caroline S. Fox +7 more
TL;DR: Lower CT attenuation of VAT and SAT is associated with adverse cardiometabolic risk above and beyond total adipose tissue volume and Qualitative indices of abdominal fat depots may provide insight regarding cardiometric risk independent of fat quantity.
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Bi-directional analysis between fatty liver and cardiovascular disease risk factors
Jiantao Ma,Shih-Jen Hwang,Alison Pedley,Joseph M. Massaro,Udo Hoffmann,Raymond T. Chung,Emelia J. Benjamin,Daniel Levy,Caroline S. Fox,Michelle T. Long +9 more
TL;DR: Bi-directional relationship between fatty liver and CVD risk factors among middle- to older-aged Framingham Heart Study participants is demonstrated and suggests non-alcoholic fatty liver disease precedes or develops after increased cardiovascular disease (CVD) risk factors.