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Amanda E. Hargrove
Researcher at Duke University
Publications - 57
Citations - 2073
Amanda E. Hargrove is an academic researcher from Duke University. The author has contributed to research in topics: RNA & Small molecule. The author has an hindex of 21, co-authored 48 publications receiving 1490 citations. Previous affiliations of Amanda E. Hargrove include California Institute of Technology & University of Texas at Austin.
Papers
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Artificial receptors for the recognition of phosphorylated molecules
Amanda E. Hargrove,Sonia Nieto,Tianzhi Zhang,Jonathan L. Sessler,Jonathan L. Sessler,Eric V. Anslyn +5 more
TL;DR: Artificial Receptors for the Recognition of Phosphorylated Molecules and their applications in drug discovery and personalized medicine are described.
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Algorithms for the determination of binding constants and enantiomeric excess in complex host : guest equilibria using optical measurements
TL;DR: An iterative method using commercial software that allows for the rigorous determination of binding constants in a variety of systems, including 1 : 2 complexes, indicator displacement assays, and enantioselective indicator displacementAssays, allowing for a more precise determination of ee in competitive equilibria.
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Probing intramolecular B-N interactions in ortho-aminomethyl arylboronic acids.
Byron E. Collins,Steven Sorey,Amanda E. Hargrove,Shagufta H. Shabbir,Vincent M. Lynch,Eric V. Anslyn +5 more
TL;DR: It was found that there is a slight increase in the amount of B-N dative bonding on going from a tertiary to a secondary to a primary amine group, but that solvent insertion dominates in all cases of the boronate esters.
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Targeting RNA in mammalian systems with small molecules.
Anita Donlic,Amanda E. Hargrove +1 more
TL;DR: Efforts toward understanding fundamental principles of small molecule–RNA recognition combined with advances in methodology development should pave the way toward targeting emerging RNA classes such as long noncoding RNAs.
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Targeting RNA with small molecules: from fundamental principles towards the clinic
TL;DR: A tutorial review of RNA-targeted small molecules can be found in this paper, highlighting the fundamental role of chemical and molecular recognition principles in enhancing our understanding of RNA biology and contributing to the rapidly growing number of RNAtargeted probes and therapeutics.