Amelia N. Pilichiewicz

TL;DR: There are major differences in the effects of intraduodenal C12 and C10, administered at 0.375 kcal/min, on appetite, energy intake, antropyloroduodanal PWs, and gut hormone release in humans.

TL;DR: In healthy subjects exogenous GLP-1 increases meal retention in the distal stomach and, even when administered in a "low" dose, frequently induces "gastroparesis", supporting the concept that GE is a major target mechanism for the clinical use of incretin mimetics.

TL;DR: Variations in duodenal glucose loads have differential effects on blood glucose, plasma insulin, GLP-1, GIP and CCK, antropyloroduodenAL motility, and energy intake in healthy subjects, and these observations have implications for strategies to minimize postprandial glycemic excursions in type 2 diabetes.

TL;DR: In conclusion, both the load, and duration, of small intestinal lipid influence antropyloroduodenal motility and patterns of CCK and PYY release.

TL;DR: In FD patients, a high-FAT meal induces more symptoms than an isocaloric high-CHO meal, and fasting and postprandial plasma CCK concentrations are greater and PYY concentrations are less, which have important implications for the development of diet-based therapies for the treatment of FD.