Showing papers by "Amir Kazory published in 2014"
TL;DR: Improved LVEF may have led to the comparatively good 1-year survival in this cohort of patients with CHRF, and PD significantly reduces the number of days of hospitalization for acute heart failure in CRHF.
Abstract: BackgroundPrevious small studies have reported favorable results of peritoneal dialysis (PD) in the setting of chronic refractory heart failure (CRHF). We evaluated the impact of PD in a larger coh...
74 citations
TL;DR: An overview of emerging controversial issues surrounding the cardiorenal interactions in ADHF is provided with the goal of identifying the areas where clinical research could be most helpful, because it is of paramount importance to characterize the pathways leading to WRF in AD HF to develop a mechanistically relevant management strategy.
38 citations
TL;DR: A number of mechanistic aspects of UF therapy are reviewed, with particular emphasis on cardio-pulmonary and cardiorenal interactions, and the results of more recent clinical trials are revisited in order to highlight the characteristics that can help identify patients who are more likely to benefit from this therapeutic modality.
Abstract: Despite major advances in pharmacological therapy and cardiac devices, heart failure patients continue to be frequently (re-)hospitalized with signs and symptoms of fluid overload. Diuretics improve the symptoms of fluid overload, but their effectiveness is reduced by a number of factors including excess salt intake, underlying chronic kidney disease, renal adaptation to their actions and neurohormonal activation. Ultrafiltration (UF) is a mechanical method of fluid removal with several potential advantages over diuretic-based conventional therapies: several recent studies have demonstrated favorable clinical response to UF therapy. Such studies have shown that removal of large amounts of isotonic fluid, in addition to relieving symptoms of congestion, can improve exercise capacity, reduce cardiac filling pressures, restore diuretic responsiveness, and portend a favorable effect on cardio-pulmonary, cardiorenal interactions, and neurohormonal hyperactivation. However, despite these proposed benefits, so far, no clinical study has yet been carried out to explore the impact of UF therapy on hard clinical endpoints such as long-term mortality. In this article, we review a number of mechanistic aspects of UF therapy, with particular emphasis on cardio-pulmonary and cardiorenal interactions, and revisit the results of more recent clinical trials in order to highlight the characteristics that can help identify patients who are more likely to benefit from this therapeutic modality.
8 citations
TL;DR: It remains to be clarified whether the medicinal effects of water would be modified by alternating periods of extreme changes in homeostatic factors such as arginine vasopressin and aldosterone levels, as well as expression of clock genes.