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Amy F.T. Arnsten
Researcher at Yale University
Publications - 232
Citations - 30139
Amy F.T. Arnsten is an academic researcher from Yale University. The author has contributed to research in topics: Prefrontal cortex & Working memory. The author has an hindex of 83, co-authored 215 publications receiving 27265 citations. Previous affiliations of Amy F.T. Arnsten include University of Connecticut & University of California, San Diego.
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Stress signalling pathways that impair prefrontal cortex structure and function
TL;DR: Recent research has provided clues as to why genetic or environmental insults that disinhibit stress signalling pathways can lead to symptoms of profound prefrontal cortical dysfunction in mental illness.
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Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory.
Susheel Vijayraghavan,Min Wang,Shari G. Birnbaum,Shari G. Birnbaum,Graham V. Williams,Amy F.T. Arnsten +5 more
TL;DR: The current study demonstrates that the D1R agonist inverted-U response can be observed in PFC neurons of behaving monkeys: low levels of D 1R stimulation enhance spatial tuning by suppressing responses to nonpreferred directions, whereas high levels reduce delay-related firing for all directions, eroding tuning.
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The Neuropsychopharmacology of Fronto-Executive Function: Monoaminergic Modulation
TL;DR: Dissociable effects of drugs and neurotoxins affecting these monoamine systems suggest new ways of conceptualizing state-dependent fronto-executive functions, with implications for understanding the molecular genetic basis of mental illness and its treatment.
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Neurobiology of Executive Functions: Catecholamine Influences on Prefrontal Cortical Functions
Amy F.T. Arnsten,Bao-Ming Li +1 more
TL;DR: Blockade of norepinephrine alpha-2-adrenoceptors in prefrontal cortex markedly impairs prefrontal cortex function and mimics most of the symptoms of attention-deficit/hyperactivity disorder, including impulsivity and locomotor hyperactivity.
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Supranormal Stimulation of D1 Dopamine Receptors in the Rodent Prefrontal Cortex Impairs Spatial Working Memory Performance
TL;DR: Results demonstrate that supranormal D1 receptor stimulation in the PFC is sufficient to impair PFC working memory function, which is consistent with recent electrophysiological studies of D1 receptors mechanisms affecting the P FC.