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Ana María Cortizo
Researcher at National University of La Plata
Publications - 84
Citations - 3139
Ana María Cortizo is an academic researcher from National University of La Plata. The author has contributed to research in topics: Osteoblast & Glycation. The author has an hindex of 34, co-authored 82 publications receiving 2884 citations.
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Osteogenic actions of the anti-diabetic drug metformin on osteoblasts in culture.
TL;DR: Results show for the first time a direct osteogenic effect of metformin on osteoblasts in culture, which could be mediated by activation/redistribution of ERK-1/2 and induction of e/iNOS.
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Effect of metformin on bone marrow progenitor cell differentiation: in vivo and in vitro studies.
M. Silvina Molinuevo,León Schurman,Antonio Desmond McCarthy,Ana María Cortizo,María José Tolosa,M. Virginia Gangoiti,Verónica Arnol,Claudia Sedlinsky +7 more
TL;DR: It is found that metformin causes an osteogenic effect both in vivo and in vitro, possibly mediated by Runx2/Cbfa1 and AMPK activation, suggesting a possible action of met formin in a shift toward the osteoblastic differentiation of BMPCs.
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A possible role of oxidative stress in the vanadium-induced cytotoxicity in the MC3T3E1 osteoblast and UMR106 osteosarcoma cell lines.
TL;DR: Results suggest that oxidative stress is involved in vanadium induced osteoblastic cytotoxicity, although the mechanism is unknown.
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Non-enzymatic glycosylation of a type I collagen matrix: effects on osteoblastic development and oxidative stress.
Antonio Desmond McCarthy,Susana B. Etcheverry,Liliana Bruzzone,Gabriela Lettieri,Daniel Alejandro Barrio,Ana María Cortizo +5 more
TL;DR: Results suggest that the accumulation of AGE on bone extracellular matrix could regulate the proliferation and differentiation of osteoblastic cells, and possibly involve the modulation of NOS expression and intracellular ROS pathways.
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Vanadium derivatives act as growth factor--mimetic compounds upon differentiation and proliferation of osteoblast-like UMR106 cells.
TL;DR: The results suggest that vanadium derivatives behave like growth factors on osteoblast-like cells and are potential pharmacological tools in the control of cell growth.