Anastasiya V. Snezhkina

TL;DR: This review covers the current data on the mechanisms of ROS generation and existing antioxidant systems balancing the redox state in mammalian cells that can also be related to tumors.

TL;DR: This review focuses on the similarities between ageing-associated and cancer-associated oxidative stress and mitochondrial dysfunction as their common phenotype and suggests that the oxidative stress as a cause and/or consequence of the mitochondrial dysfunction is one of the main drivers of these processes.

TL;DR: The present review discusses the most important and well-studied CRC biomarkers, and their potential clinical significance and current approaches to molecular classification of colorectal tumors.

TL;DR: The role of GAPDH in carcinogenesis and the possibility of using this target for anticancer therapy is focused on and limitations of this approach may come from the versatility of the GAPDh enzyme, since it combines glycolytic, pro-apoptotic and other activities.

TL;DR: Two mediators of metabolic reprogramming, inflammation, and cell proliferation c-Myc and C/EBPβ may serve as regulators of polyamine metabolism genes (SMOX, AZIN1, MTAP, SRM, ODC1, AMD1, and AGMAT) as they are overexpressed in tumors, have binding site according to ENCODE ChIP-Seq data, and demonstrate strong coexpression with their targets.