The present invention includes dry powder inhalers for dispensing and/or holding inhalant formulated dry powder substances and associated fabrication and dispensing methods that can employ an amplitude modulated non-linear signal comprising a plurality of superimposed frequencies, the frequencies corresponding to a priori flow characteristic frequencies of the dry powder being dispensed. The present invention also includes pocket-sized inhalers with an elastomeric flexible pivoting cover.

Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages

A dry powder inhaler comprises a main airflow path including a cyclone chamber (16) having an air inlet and being so shaped that at least a part of the chamber decreases in cross-sectional area in a direction away from the air inlet, so as thereby in use to set up a reverse flow cyclone in the chamber. A bypass airflow path (8) bypasses the cyclone chamber and the main and bypass airflow paths communicate with a mouthpiece (6). The cyclone chamber may be provided by a part (22) which is removable from the rest of the inhaler for regular replacement thereof.

Dry powder inhalers

A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.

Dry powder inhaler and system for drug delivery

Methods are provided for drying a particle. Specifically, there is provided a spray-dried diketopiperazine-insulin particle formulation having improved aerodynamic performance and in which the active agent is more stabile and efficiently delivered as compared to that of the lyophilized diketopiperazine-insulin formulation. The dry powders have utility as pharmaceutical formulations for pulmonary delivery.

Method for Improving the Pharmaceutic Properties of Microparticles Comprising Diketopiperazine and an Active Agent

Methods are provided for coating crystalline microparticles with an active agent by altering the surface properties of the microparticles in order to facilitate favorable association on the microparticle by the active agent. Type of surface properties that are altered by the disclosed methods include by electrostatic properties, hydrophobic properties and hydrogen bonding properties.

Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents

The present invention relates to a blister pack (12) having a plurality of blisters (13) each holding a dose of a powdered medicament comprising a lower base (18) containing a plurality of cavities (19) for the powdered medicament and an upper sealing foil layer (20) which covers the lower base (18) to form the blisters (13). Each cavity (19) is provided with at least one adjacent slit (21) formed by scoring the foil layer (20) and a lower base (18). The slit (21) ensuring accurate penetration of a cavity (19) by a suction tube through which a user can inhale the contents of the cavity (19).

Anders Selmer

Papers

Inhalation device employing blister packs with cavities and alignment slits

An inhalation device