A
Andrea Beucher
Researcher at Technische Universität Darmstadt
Publications - 7
Citations - 1581
Andrea Beucher is an academic researcher from Technische Universität Darmstadt. The author has contributed to research in topics: DNA repair & Homologous recombination. The author has an hindex of 6, co-authored 7 publications receiving 1440 citations. Previous affiliations of Andrea Beucher include Saarland University.
Papers
More filters
Journal ArticleDOI
γH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization
Markus Löbrich,Atsushi Shibata,Andrea Beucher,Anna Fisher,Michael Ensminger,Aaron A. Goodarzi,Olivia Barton,Penny A. Jeggo +7 more
TL;DR: Evidence is presented that following exposure to ionising radiation, γH2AX foci analysis can provide a sensitive monitor of DSB formation and repair and techniques to optimise the analysis are described, enabling the procedure to be optimally exploited but not misused.
Journal ArticleDOI
ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2.
Andrea Beucher,Julie Birraux,Leopoldine Tchouandong,Olivia Barton,Atsushi Shibata,Sandro Conrad,Aaron A. Goodarzi,Andrea Krempler,Penny A. Jeggo,Markus Löbrich +9 more
TL;DR: It is shown that in G2, as in G1, NHEJ represents the major DSB‐repair pathway whereas HR is only essential for repair of ∼15% of X‐ or γ‐ray‐induced DSBs.
Journal ArticleDOI
Chromosome breakage after G2 checkpoint release
Dorothee Deckbar,Julie Birraux,Andrea Krempler,Leopoldine Tchouandong,Andrea Beucher,Sarah Cusworth Walker,Tom Stiff,Penny A. Jeggo,Markus Löbrich +8 more
TL;DR: The efficiency and interplay of ATM's G2 checkpoint and repair functions are examined, showing that checkpoint release occurs at a point when approximately three to four premature chromosome condensation breaks and ∼20 γH2AX foci remain.
Journal ArticleDOI
CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1
TL;DR: It is shown that human cells arrested in G0/G1 repair etoposide-induced DSBs by NHEJ and, surprisingly, require the MRN complex (the ortholog of MRX) and CtIP.
ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.Thislicensedoesnot permit commercial exploitation without specific permission.
Andrea Beucher,Julie Birraux,Leopoldine Tchouandong,Olivia Barton,Atsushi Shibata,Sandro Conrad,Aaron A. Goodarzi,Andrea Krempler,Penny A. Jeggo,Markus Löbrich +9 more
TL;DR: In this paper, the authors show that in G2, NHEJ represents the major DSB-repair pathway whereas HR is only essential for repair of B15% of X- or c-ray-induced DSBs.