Showing papers by "Andreas Herrmann published in 1992"
TL;DR: The Ca2+ threshold of fusion of lipid-asymmetric red blood cells was significantly reduced after exposure of PS to the outer layer but not after redistribution of PE alone, and upon incorporation of spin-labeled PS into the outer leaflet of redBlood cells, suggesting that the serine headgroup is an important factor in calcium-phosphate-induced fusion.
26 citations
TL;DR: The hydropathy profile of hemagglutinin subunits HA1 and HA2 of influenza virus X31 and A/PR 8/34 is analyzed at different pH and it is suggested that these hydrophobic stretches are important for the fusion complex, in addition to the N-terminal site of HA2.
Abstract: The hydropathy profile of hemagglutinin (HA) subunits HA1 and HA2 of influenza virus X31 and A/PR 8/34 is analyzed at different pH. At neutral pH (7.4) pronounced hydrophobic sequences of HA correspond to the N-terminus and the transmembrane spanning sequence of HA2. At pH 5.0 where influenza virus is known to fuse with biological membranes several hydrophobic sequences in the ectodomain exist which are comparable in both the hydrophobicity and length of the N-terminus of HA2. It is suggested that these hydrophobic stretches are important for the fusion complex, in addition to the N-terminal site of HA2.
19 citations
TL;DR: Evidence is given that the conformational change of the virus envelope protein hemagglutinin (HA) responsible for triggering fusion is not affected by the polymer, and Hemolysis of intact red blood cells by influenza A virus at low pH values is also prevented by dextran sulfate.
11 citations