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Andrés J. García
Researcher at Georgia Institute of Technology
Publications - 401
Citations - 27232
Andrés J. García is an academic researcher from Georgia Institute of Technology. The author has contributed to research in topics: Integrin & Self-healing hydrogels. The author has an hindex of 87, co-authored 377 publications receiving 24040 citations. Previous affiliations of Andrés J. García include Parker H. Petit Institute for Bioengineering & Bioscience & Georgia Tech Research Institute.
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Surface chemistry modulates fibronectin conformation and directs integrin binding and specificity to control cell adhesion
TL;DR: An experimental framework to analyze adhesive mechanisms controlling cell-surface interactions is established and a general strategy of surface-directed control of adsorbed protein activity to manipulate cell function in biomaterial and biotechnological applications is provided.
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Modulation of Cell Proliferation and Differentiation through Substrate-dependent Changes in Fibronectin Conformation
TL;DR: It is demonstrated that substrate-dependent changes in the conformation of adsorbed fibronectin (Fn) modulated integrin binding and controlled switching between proliferation and differentiation.
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Demonstration of catch bonds between an integrin and its ligand
TL;DR: Catch bond formation appears to involve force-assisted activation of the headpiece but not integrin extension, and binding of monoclonal antibodies that induce the active conformation of the integrin headpiece shifted catch bonds to a lower force range.
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Integrin binding specificity regulates biomaterial surface chemistry effects on cell differentiation
TL;DR: It is demonstrated that surface chemistry modulates osteoblastic differentiation and matrix mineralization independently from alterations in cell proliferation, establishing surface-dependent differences in integrin binding as a mechanism regulating differential cellular responses to biomaterial surfaces.
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Surface chemistry modulates focal adhesion composition and signaling through changes in integrin binding.
TL;DR: Investigation of the effects of surface chemistry on focal adhesion assembly and signaling in a model system with well-defined chemistries revealed that surface chemistry modulates the structure and molecular composition of cell-matrix adhesions as well as focalAdhesion kinase (FAK) signaling.