Andressa Brito Lira

TL;DR: The A. occidentale extract has potential as an antimicrobial agent with low eukaryotic cell toxicity or mutagenic activity, and might as well be a safe and effective phytotherapeutic alternative.

TL;DR: Preliminary quantitative structure-activity relationship (QSAR) analyses confirmed that certain structural characteristics, such as a median linear carbon chain and the presence of electron withdrawal substituents at the para position of the aromatic ring, help potentiate antibacterial activity.

TL;DR: It was concluded that the analyzed compounds have various pharmacological activities in accordance with the predictions of PASS online, as their antibacterial and antioxidant activities were confirmed.

TL;DR: The extract presented steroids, tannins, flavonoids and saponins, compounds that had already been found in other studies of this species, and presented high toxicity to A. salina, serving as a parameter for the accomplishment of later studies in animal models.

TL;DR: The results showed that isopropyl caffeate presents no significant theoretical risk of toxicity, with likely moderate bioactivity: GPCR binding, ion channel modulation, nuclear receptor binding, and enzyme inhibition, but moderate toxicity was demonstrated through depressant effects on the central nervous system.