Andrew Thomas

TL;DR: In this article, the authors highlight the recent developments in the copper-mediated (both stoichiometric and catalytic) reactions of aryl boronic acids as reaction partners in both O- and N-arylation.

TL;DR: This Perspective highlights some of the most pressing challenges to be overcome from the industrial viewpoint — such as the development of reactions tolerating specific functionalities — and encourages stronger industry–academia relationships.

TL;DR: In this paper, the Palladium-vermittelten Arylierungsreaktionen are defined as Kupplungs-reaktionsen with einer grosen Bandbreite an Substraten.

TL;DR: RO4938581 is a potent inverse agonist at the GABAA α5 receptor, with both binding and functional selectivity, enhancing hippocampal LTP, and further support the potential of GAB AA α5 receptors as a target for cognition-enhancing drugs.

TL;DR: Reducing GABAergic inhibition with RO4938581 can reverse functional and neuromorphological deficits of TS mice by facilitating brain plasticity and support the potential therapeutic use of selective GABAA α5 NAMs to treat cognitive dysfunction in DS.