Deep eutectic solvents, as an alternative to ionic liquids, have greener credentials than ionic liquids, and have attracted considerable attention in related chemical research. Deep eutectic solvents have attracted increasing attention in chemistry for the extraction and separation of various target compounds from natural products. This review highlights the preparation of deep eutectic solvents, unique properties of deep eutectic solvents, and synthesis of deep-eutectic-solvent-based materials. On the other hand, application in the extraction and separation of deep eutectic solvents is also included in this report. In this paper, the available data and references in this field are reviewed to summarize the applications and developments of deep eutectic solvents. Based on the development of deep eutectic solvents, an exploitation of new deep eutectic solvents and deep eutectic solvents-based materials is expected to diversify into extraction and separation.

Development of deep eutectic solvents applied in extraction and separation.

Ionic liquids (ILs) have now been acknowledged as reaction media for biotransformations. The first three examples were reported in this field in 2000, and since then, numerous applications have been reported for biocatalytic reactions using ILs. Two topics using ILs for enzymatic reactions have been reviewed from the standpoint of biocatalyst mediating organic synthesis; the first is “Biocatalysis in Ionic Liquids” which includes various types of biocatalytic reactions in ILs (section 2): (1) recent examples of lipase-mediated reactions using ILs as reaction media for biodiesel oil production and for sugar ester production, (2) oxidase-catalyzed reactions in ILs, (3) laccase-catalyzed reactions, (4) peroxidase-catalyzed reactions, (4) cytochrome-mediated reactions, (5) microbe-mediated hydrations, (6) protease-catalyzed reactions, (8) whole cell mediated asymmetric reduction of ketones, (10) acylase-catalyzed reactions, (11) glycosylation or cellulase-mediated hydrolysis of polysaccharides, (12) hydroxyni...

Ionic Liquids as Tool to Improve Enzymatic Organic Synthesis.

Deep Eutectic Solvents

Formation of type III Deep Eutectic Solvents and effect of water on their intermolecular interactions

Recent developments on ultrasound assisted catalyst-free organic synthesis.

Chitosan is a cationic natural polysaccharide, which has emerged as an increasingly interesting biomaterialover the past few years. It constitutes a novel perspective in drug delivery systems and nanocarriers' formulations due to its beneficial properties, including biocompatibility, biodegradability and low toxicity. The potentiality of chemical or enzymatic modifications of the biopolymer, as well as its complementary use with other polymers, further attract the scientific community, offering improved and combined properties in the final materials. As a result, chitosan has been extensively used as a matrix for the encapsulation of several valuable compounds. In this review article, the advantageous character of chitosan as a matrix for nanosystemsis presented, focusing on the encapsulation of natural products. A five-year literature review is attempted covering the use of chitosan and modified chitosan as matrices and coatings for the encapsulation of natural extracts, essential oils or pure naturally occurring bioactive compounds are discussed.

https://www.mdpi.com/1999-4923/12/7/669/pdf

Nanosystems for the Encapsulation of Natural Products: The Case of Chitosan Biopolymer as a Matrix

Choline chloride and tartaric acid, a Natural Deep Eutectic Solvent for the efficient extraction of phenolic and carotenoid compounds

Separation of the ethanol/water azeotropic mixture using ionic liquids and deep eutectic solvents

In the frame of research that examines the use of task-specific ionic liquids (ILs) for developing green methodologies toward novel bioactive compounds, ethanolamine-derived ILs were synthesized and used as solvents and catalysts in a domino Knoevenagel–Michael reaction. After extended optimization studies regarding the most important reaction parameters such as reaction time, temperature, and molar ratio of reactants, it was ascertained that the reaction between 4-hydroxy-coumarin and various benzaldehydes in the synthesized ILs proceeded smoothly at 40 °C in 3 h, providing the desired biscoumarins in very satisfactory yields (up to 97%) and high purity after simple workup. The task-specific ILs were recycled and reused three times without a noticeable decrease in their catalytic activity. Moreover, the biodegradability potential of the synthesized ILs has been investigated by applying the biological oxygen demand (BOD-5) closed bottle test. The results indicated that organic carbon was biodegraded up to...

Andromachi Tzani

Papers

Nanosystems for the Encapsulation of Natural Products: The Case of Chitosan Biopolymer as a Matrix

Choline chloride and tartaric acid, a Natural Deep Eutectic Solvent for the efficient extraction of phenolic and carotenoid compounds

Separation of the ethanol/water azeotropic mixture using ionic liquids and deep eutectic solvents

Synthesis of Biscoumarins Using Recyclable and Biodegradable Task-Specific Ionic Liquids

Ionic liquids as entrainers for the separation of the ethanol/water system