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Andy Wullaert
Researcher at Ghent University
Publications - 43
Citations - 4108
Andy Wullaert is an academic researcher from Ghent University. The author has contributed to research in topics: Inflammasome & Inflammation. The author has an hindex of 24, co-authored 40 publications receiving 3436 citations. Previous affiliations of Andy Wullaert include University of Cologne & Flanders Institute for Biotechnology.
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Journal ArticleDOI
Epithelial NEMO links innate immunity to chronic intestinal inflammation
Arianna Nenci,Christoph Becker,Andy Wullaert,Ralph Gareus,Geert van Loo,Silvio Danese,Marion Huth,Alexei Nikolaev,Clemens Neufert,Blair B. Madison,Deborah L. Gumucio,Markus F. Neurath,Manolis Pasparakis +12 more
TL;DR: It is demonstrated that a primary NF-κB signalling defect in intestinal epithelial cells disrupts immune homeostasis in the gastrointestinal tract, causing an inflammatory-bowel-disease-like phenotype.
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FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation
Patrick-Simon Welz,Andy Wullaert,Katerina Vlantis,Vangelis Kondylis,Vanesa Fernández-Majada,Maria A. Ermolaeva,Petra Kirsch,Anja Sterner-Kock,Geert van Loo,Manolis Pasparakis +9 more
TL;DR: By inhibiting RIP3-mediated IEC necrosis, FADD preserves epithelial barrier integrity and antibacterial defence, maintains homeostasis and prevents chronic intestinal inflammation, indicating that programmed necrosis of IECs might be implicated in the pathogenesis of inflammatory bowel disease.
Journal ArticleDOI
NF-κB in the regulation of epithelial homeostasis and inflammation.
TL;DR: It is suggested that NF-κB signaling has important functions for the maintenance of physiological immune homeostasis and for the prevention of inflammatory diseases in many tissues, and the mechanisms that control these apparently opposing functions of NF-kkB signaling are discussed.
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Mechanisms of crosstalk between TNF-induced NF-kappaB and JNK activation in hepatocytes.
TL;DR: The various mechanisms by which NF-kappaB activation blunts TNF-induced JNK activation are discussed, including the induction of JNK inhibitory proteins and controlling the levels of reactive oxygen species (ROS).
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Hepatic tumor necrosis factor signaling and nuclear factor-kappaB: effects on liver homeostasis and beyond.
TL;DR: A number of genetic studies recently obtained conflicting results on the exact role of NF-kappaB in different mouse models of TNF hepatotoxicity, demonstrating that caution should be taken when interpreting studies using different NF- kappaB-deficient mice in distinct models of liver injury.