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Ang-Chen Tsai
Researcher at Florida A&M University – Florida State University College of Engineering
Publications - 24
Citations - 831
Ang-Chen Tsai is an academic researcher from Florida A&M University – Florida State University College of Engineering. The author has contributed to research in topics: Mesenchymal stem cell & Microcarrier. The author has an hindex of 11, co-authored 22 publications receiving 625 citations. Previous affiliations of Ang-Chen Tsai include University of Florida & Florida State University.
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Three-Dimensional Aggregates of Mesenchymal Stem Cells: Cellular Mechanisms, Biological Properties, and Applications
TL;DR: Recent reports of MSC aggregate self-assembly, characterization of biological properties, and their applications in preclinical models are summarized to provide perspectives for identifying the controlling mechanisms and refining the methods of aggregate fabrication and expansion for clinical applications.
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Compaction, Fusion, and Functional Activation of Three-Dimensional Human Mesenchymal Stem Cell Aggregate
TL;DR: Multicellular aggregation as an effective and nongenetic strategy for hMSC functional activation is suggested and comparable ATP/cell levels and significantly reduced mitochondrial membrane potential in aggregates of different sizes suggest that altered mitochondria bioenergetics on 3D aggregation is the primary inducer for apoptosis.
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Influence of Microenvironment on Mesenchymal Stem Cell Therapeutic Potency: From Planar Culture to Microcarriers
TL;DR: Fundamental principles and concepts for future design of biomanufacturing systems for hMSC-based therapy are addressed and bioprocessing parameters encountered in planar culture and microcarrier-based bioreactor culture of hMSCs are compared.
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Metabolic Reconfiguration Supports Reacquisition of Primitive Phenotype in Human Mesenchymal Stem Cell Aggregates.
TL;DR: Results show that aggregation changes mitochondrial morphology and reduces mitochondrial membrane potential, resulting in a metabolic reconfiguration characterized by increased glycolytic and anaplerotic flux, and activation of autophagy.
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Aggregation kinetics of human mesenchymal stem cells under wave motion
TL;DR: The results show that the hMSC aggregation is mediated by cell adhesion molecules and that aggregate size distribution is influenced by seeding density, culture time, and hydrodynamic conditions, and that the rocking angle had a more pronounced effect on aggregate sizes than the rocking speed.