Angela Oberhofer

TL;DR: The results unmasked the regulatory dominance of the melanophilin adaptor protein over its associated motor and offer an unexpected mechanism by which filaments of the cytoskeletal network compete for the moving organelles to accomplish directional transport on the cytOSkeleton in vivo.

TL;DR: Top-up reconstitution and theoretical approaches are combined to systematically dissect the underlying mechanistic principles of cytoskeletal cross-talk using the example of cell-wide organelle transport and describe the emergence of a protein domain that confers the capability of interacting with both filament types onto melanophilin.

TL;DR: This novel tissue-of origin-analysis enables to estimate the contributions of different tissues to the total cfDNA pool in body fluids and find tissues with increased cell death (pathologic condition), expanding the portfolio of liquid biopsies towards a wide range of pathologies and early diagnosis.

TL;DR: How expanded knowledge on cfDNA biology and faithful reverse-engineering of cfDNA samples promises to augment the sensitivity and specificity of existing cfDNA assays, expand the repertoire of disease-specific cfDNA markers, and reshape personal molecular medicine are shown to have an unprecedented impact on genetics research are shown.

TL;DR: A significant difference is demonstrated between cancer patients and healthy subjects for some preanalytical workflows, while other workflows failed to yield statistically significant differences, underscoring the importance of controlling and standardizing pre Analytical procedures in the development of clinical assays based on the measurement of mtDNA.